Mixed metal-organic framework mixed-matrix membranes : insights into simultaneous moisture-triggered and catalytic delivery of nitric oxide using cryo-scanning electron microscopy
Date
25/10/2023Author
Grant ID
787073
EP/T019298/1
EP/R023751/1
Keywords
Metadata
Show full item recordAbstract
The fundamental chemical and structural diversity of metal–organic frameworks (MOFs) is vast, but there is a lack of industrial adoption of these extremely versatile compounds. To bridge the gap between basic research and industry, MOF powders must be formulated into more application-relevant shapes and/or composites. Successful incorporation of varying ratios of two different MOFs, CPO-27-Ni and CuBTTri, in a thin polymer film represents an important step toward the development of mixed MOF mixed-matrix membranes. To gain insight into the distribution of the two different MOFs in the polymer, we report their investigation by Cryo-scanning electron microscopy (Cryo-SEM) tomography, which minimizes surface charging and electron beam-induced damage. Because the MOFs are based on two different metal ions, Ni and Cu, the elemental maps of the MOF composite cross sections clearly identify the size and location of each MOF in the reconstructed 3D model. The tomography run was about six times faster than conventional focused ion beam (FIB)-SEM and the first insights to image segmentation combined with machine learning could be achieved. To verify that the MOF composites combined the benefits of rapid moisture-triggered release of nitric oxide (NO) from CPO-27-Ni with the continuous catalytic generation of NO from CuBTTri, we characterized their ability to deliver NO individually and simultaneously. These MOF composites show great promise to achieve optimal dual NO delivery in real-world medical applications.
Citation
Ettlinger , R , Vornholt , S , Roach , M , Tuttle , R , Thai , J , Kothari , M , Boese , M , Holwell , A , Duncan , M J , Reynolds , M & Morris , R E 2023 , ' Mixed metal-organic framework mixed-matrix membranes : insights into simultaneous moisture-triggered and catalytic delivery of nitric oxide using cryo-scanning electron microscopy ' , ACS Applied Materials & Interfaces , vol. 15 , no. 42 , pp. 49835-49842 . https://doi.org/10.1021/acsami.3c11283
Publication
ACS Applied Materials & Interfaces
Status
Peer reviewed
ISSN
1944-8244Type
Journal article
Description
Funding: This work was supported by the European Research Council grant ADOR (Advanced Grant 787073). The authors acknowledge the EPSRC Light Element Analysis Facility Grant (EP/T019298/1) and the EPSRC Strategic Equipment Resource Grant (EP/R023751/1).Collections
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