Organophotocatalytic radical-polar cross-coupling of styrene boronic acids and redox-active esters
Abstract
We report the development of a radical-polar cross-coupling reaction using styrene boronic acids and redox-active esters under organophotoredox catalysis. The reaction proceeds through a formal polarity-mismatched radical addition. The use of an organic photocatalyst enabled very low loadings of the electron-shuttle additive and accelerated reaction times compared to established processes. The scope of the reaction is explored, and the utility of the products is demonstrated.
Citation
Brals , J , D'Arcy-Evans , N , McGuire , T & Watson , A J B 2023 , ' Organophotocatalytic radical-polar cross-coupling of styrene boronic acids and redox-active esters ' , Synlett , vol. 34 , pp. A-D . https://doi.org/10.1055/a-2179-6570
Publication
Synlett
Status
Peer reviewed
ISSN
0936-5214Type
Journal article
Description
Funding: AstraZeneca; EPSRC - EP/W007517; Leverhulme Trust - RF-2022-014.Collections
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