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Title: Dissection of genetic associations with language-related traits in population-based cohorts
Authors: Paracchini, Silvia
Keywords: Epidemiology
Quantitative genetics
Association studies
Neurodevelopmental disorders
QH426 Genetics
Issue Date: 2011
Citation: Paracchini , S 2011 , ' Dissection of genetic associations with language-related traits in population-based cohorts ' Journal of Neurodevelopmental Disorders , vol 3 , no. 4 , pp. 365-373 . , 10.1007/s11689-011-9091-6
Abstract: Recent advances in the field of language-related disorders have led to the identification of candidate genes for specific language impairment (SLI) and dyslexia. Replication studies have been conducted in independent samples including population-based cohorts, which can be characterised for a large number of relevant cognitive measures. The availability of a wide range of phenotypes allows us to not only identify the most suitable traits for replication of genetic association but also to refine the associated cognitive trait. In addition, it is possible to test for pleiotropic effects across multiple phenotypes which could explain the extensive comorbidity observed across SLI, dyslexia and other neurodevelopmental disorders. The availability of genome-wide genotype data for such cohorts will facilitate this kind of analysis but important issues, such as multiple test corrections, have to be taken into account considering that small effect sizes are expected to underlie such associations.
Version: Publisher PDF
Description: The author was supported by the Wellcome Trust [076566/Z/05/Z]; [075491/Z/04] and the Medical Research Council [G0800523/86473].
Status: Peer reviewed
ISSN: 1866-1947
Type: Journal item
Rights: (c) The Author 2011. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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