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dc.contributor.authorChakakala-Chaziya, Jessica
dc.contributor.authorPatson, Noel
dc.contributor.authorSamuel, Vincent
dc.contributor.authorMbotwa, John
dc.contributor.authorBuonsenso, Danilo
dc.contributor.authorChisale, Master
dc.contributor.authorPhiri, Eddie
dc.contributor.authorO'Hare, Bernadette Ann-Marie
dc.identifier.citationChakakala-Chaziya , J , Patson , N , Samuel , V , Mbotwa , J , Buonsenso , D , Chisale , M , Phiri , E & O'Hare , B A-M 2023 , ' A comparison of clinical outcomes among people living with HIV of different age groups attending Queen Elizabeth Central Hospital Outpatient ART Clinic in Malawi ' , Frontiers in Medicine , vol. 10 , 1175553 .
dc.identifier.otherPURE: 293954371
dc.identifier.otherPURE UUID: 238f46eb-156f-44ca-af60-dc4f8f972b8b
dc.identifier.otherORCID: /0000-0003-1730-7941/work/142904660
dc.identifier.otherScopus: 85173565330
dc.description.abstractIntroduction: Adherence to Antiretroviral Treatment (ART) in children and adolescents living with HIV in low-resource settings is not extensively studied in large cohort studies including both adults and pediatric patients. We compared rates of virological suppression, adherence and defaulting among children, adolescents and adults attending a family ART clinic at Queen Elizabeth Central Hospital; a tertiary hospital situated in the southern region of Malawi. Methods: The study was longitudinal and made use of routinely collected data for all 27,229 clinic attendees. Clinical information obtained at routine clinical visits entered electronically since 2008 was extracted in February 2017. This data was used to ascertain differences across the different age groups. Logistic regression and Cox regression models were fitted to compare rates of Virological Suppression (VS), adherence, and defaulting, respectively. Results: Younger and older adolescents (ages 10–14 years and 15–19 years respectively) were less likely to achieve VS compared to adults in the final model AOR 0.4 (0.2–0.9, 95% CI) and AOR 0.2 (0.1–0.4, 95% CI) respectively. Young children (ages 0–4 years), older children (ages 5–9 years) and younger adolescents were less adherent to ART compared to adults AOR 0.1 (0.1–0.2, 95% CI), AOR 0.2 (0.1–0.3, 95% CI), and AOR 0.4 (0.3–0.5, 95% CI) respectively. Young adults and younger children had an increased likelihood of defaulting compared to adults. Conclusion: Poor performance on ART of children and adolescents highlights unaddressed challenges to adherence. Ongoing research to explore these potential barriers and possible interventions needs to be carried out. The adherence assessment methods used and strategies for improving it among children and adolescents need to be revised at the clinic.
dc.relation.ispartofFrontiers in Medicineen
dc.rightsCopyright © 2023 Chakakala-Chaziya, Patson, Samuel, Mbotwa, Buonsenso, Chisale, Phiri and O’Hare. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleA comparison of clinical outcomes among people living with HIV of different age groups attending Queen Elizabeth Central Hospital Outpatient ART Clinic in Malawien
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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