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dc.contributor.authorPersheyev, Saydulla
dc.contributor.authorSamuel, Ifor David William
dc.contributor.authorSmith, Terry K
dc.identifier.citationPersheyev , S , Samuel , I D W & Smith , T K 2023 , ' Organic and inorganic light-emitting diodes for photodynamic therapy of cutaneous Leishmaniasis ' , Global Journal of Infectious Diseases and Clinical Research , vol. 9 , no. 1 , pp. 025-030 .
dc.descriptionFunding: Royal Society Global Challenge grant CH160144.en
dc.description.abstractFor effectively fighting worldwide infectious diseases such as cutaneous Leishmaniasis, novel approaches are required. Photodynamic Therapy (PDT) is one such possibility. PDT involves applying a light-sensitive chemical (photosensitizer), which should be highly efficient, non-toxic, and work at longer light wavelengths. This photosensitizer needs to be activated by a light source that provides uniform emission over a large area, high intensity, easy to fabricate, compact, and low cost. In this work, we designed and built light sources based upon commercially available Organic Light Emitting Diode (OLED) and LED parts to experimentally validate the combination with methylene blue photosensitizer to kill Leishmania major and Crithidia fasciculata cells in vitro. Our results showed that suitable-sized OLEDs, as compact and uniform light sources, are very good candidates for photodynamic therapy and can be used to efficiently kill such kinetoplastids in vitro. Therefore, it has real potential to be used in wearable devices for ambulatory treatment of patients.
dc.relation.ispartofGlobal Journal of Infectious Diseases and Clinical Researchen
dc.subjectLeishmania majoren
dc.subjectCrithidia fasciculataen
dc.subjectIn vitroen
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectRM Therapeutics. Pharmacologyen
dc.titleOrganic and inorganic light-emitting diodes for photodynamic therapy of cutaneous Leishmaniasisen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Condensed Matter Physicsen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.description.statusPeer revieweden

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