Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
Abstract
Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.
Citation
Fang , Q , Frewer , L , Wijesinghe , P , Allen , W M , Chin , L , Hamzah , J , Sampson , D D , Curatolo , A & Ennedy , B F K 2017 , ' Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces ' , Optics Letters , vol. 42 , no. 7 , pp. 1233-1236 . https://doi.org/10.1364/OL.42.001233
Publication
Optics Letters
Status
Peer reviewed
ISSN
0146-9592Type
Journal article
Description
Australian Research Council (ARC); National Health and Medical Research Council (NHMRC); National Breast Cancer Foundation (NBCF); Department of Health, Government of Western Australia.Collections
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