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dc.contributor.authorImoesi, Peter I.
dc.contributor.authorOlarte-Sánchez, Cristian M.
dc.contributor.authorCroce, Lorenzo
dc.contributor.authorBlaner, William S.
dc.contributor.authorMorgan, Peter J.
dc.contributor.authorHeisler, Lora
dc.contributor.authorMcCaffery, Peter
dc.date.accessioned2023-08-15T15:30:09Z
dc.date.available2023-08-15T15:30:09Z
dc.date.issued2023-08-18
dc.identifier292461364
dc.identifier8c937d67-67c6-4a82-83b7-c85015a7091a
dc.identifier85166662263
dc.identifier.citationImoesi , P I , Olarte-Sánchez , C M , Croce , L , Blaner , W S , Morgan , P J , Heisler , L & McCaffery , P 2023 , ' Control by the brain of vitamin A homeostasis ' , iScience , vol. 26 , no. 8 , 107373 . https://doi.org/10.1016/j.isci.2023.107373en
dc.identifier.issn2589-0042
dc.identifier.otherORCID: /0000-0002-1393-5708/work/140829677
dc.identifier.urihttps://hdl.handle.net/10023/28179
dc.descriptionFunding: PJMc acknowledges funding from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) grant number BB/T00875X/1 , the University of Aberdeen Elphinstone PhD Scholarship , Sir Richard Stapley Educational Trust , and home sponsor for PII. PJM acknowledges support from the Rural and Environment Science and Analytical Services Division (RESAS) division of the Scottish Government. LKH acknowledges funding from the BBSRC ( BB/R01857X/1 ; BBV016849/1 ). Further support was received from BBSRC grant BB/P004806/1 . Also acknowledged is funding from an MRC Discovery award ( MRC/PC/15077 ).en
dc.description.abstractVitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.
dc.format.extent18
dc.format.extent4999619
dc.language.isoeng
dc.relation.ispartofiScienceen
dc.subjectBiological sciencesen
dc.subjectEndocrinologyen
dc.subjectNatural sciencesen
dc.subjectNeuroscienceen
dc.subjectPhysiologyen
dc.subjectRC Internal medicineen
dc.subjectGeneralen
dc.subjectNDASen
dc.subjectMCCen
dc.subject.lccRCen
dc.titleControl by the brain of vitamin A homeostasisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1016/j.isci.2023.107373
dc.description.statusPeer revieweden


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