Show simple item record

Files in this item


Item metadata

dc.contributor.authorImoesi, Peter I.
dc.contributor.authorOlarte-Sánchez, Cristian M.
dc.contributor.authorCroce, Lorenzo
dc.contributor.authorBlaner, William S.
dc.contributor.authorMorgan, Peter J.
dc.contributor.authorHeisler, Lora
dc.contributor.authorMcCaffery, Peter
dc.identifier.citationImoesi , P I , Olarte-Sánchez , C M , Croce , L , Blaner , W S , Morgan , P J , Heisler , L & McCaffery , P 2023 , ' Control by the brain of vitamin A homeostasis ' , iScience , vol. 26 , no. 8 , 107373 .
dc.identifier.otherPURE: 292461364
dc.identifier.otherPURE UUID: 8c937d67-67c6-4a82-83b7-c85015a7091a
dc.identifier.otherScopus: 85166662263
dc.identifier.otherORCID: /0000-0002-1393-5708/work/140829677
dc.descriptionFunding: PJMc acknowledges funding from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) grant number BB/T00875X/1 , the University of Aberdeen Elphinstone PhD Scholarship , Sir Richard Stapley Educational Trust , and home sponsor for PII. PJM acknowledges support from the Rural and Environment Science and Analytical Services Division (RESAS) division of the Scottish Government. LKH acknowledges funding from the BBSRC ( BB/R01857X/1 ; BBV016849/1 ). Further support was received from BBSRC grant BB/P004806/1 . Also acknowledged is funding from an MRC Discovery award ( MRC/PC/15077 ).en
dc.description.abstractVitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.
dc.rightsCopyright © 2023 The Author(s). This is an open access article under the CC BY license (
dc.subjectBiological sciencesen
dc.subjectNatural sciencesen
dc.subjectRC Internal medicineen
dc.titleControl by the brain of vitamin A homeostasisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record