Show simple item record

Files in this item


Item metadata

dc.contributor.authorPavez-Fox, Melissa A.
dc.contributor.authorNegron-Del Valle, Josue E.
dc.contributor.authorThompson, Indya J.
dc.contributor.authorWalker, Chistopher S.
dc.contributor.authorBauman, Samuel E.
dc.contributor.authorGonzalez, Olga
dc.contributor.authorCompo, Nicole
dc.contributor.authorRuiz-Lambides, Angelina
dc.contributor.authorMartinez, Melween I.
dc.contributor.authorPlatt, Michael L.
dc.contributor.authorMontague, Michael J.
dc.contributor.authorHigham, James P.
dc.contributor.authorSnyder-Mackler, Noah
dc.contributor.authorBrent, Lauren J.N.
dc.identifier.citationPavez-Fox , M A , Negron-Del Valle , J E , Thompson , I J , Walker , C S , Bauman , S E , Gonzalez , O , Compo , N , Ruiz-Lambides , A , Martinez , M I , Platt , M L , Montague , M J , Higham , J P , Snyder-Mackler , N & Brent , L J N 2021 , ' Sociality predicts individual variation in the immunity of free-ranging rhesus macaques ' , Physiology & Behavior , vol. 241 , 113560 .
dc.identifier.otherPURE: 292414357
dc.identifier.otherPURE UUID: 558923c4-91ce-4313-8139-4da02b5c9956
dc.identifier.otherScopus: 85113621773
dc.descriptionFunding: This work was supported by CONICYT-Chilean scholarship [number 72190290], NIH grant [number R01AG060931] to N.S-M., L.J.N.B. and J.P.H., NIH grant [number R00AG051764] to N.S-M., NIH grant [number MH118203] to L.J.N.B.. and M.L.P, and NSF grant [number 1800558] to J.P.H. and Susan Anton. The CPRC is supported by the National Institutes of Health. An Animal and Biological Material Resource Center Grant [P40OD012217] was awarded to UPR from the Office of Research Infrastructure Programs (ORIP), and a Research Facilities Construction Grant [C06OD026690] was awarded for the renovation of CPRC facilities after Hurricane Maria.en
dc.description.abstractSocial integration and social status can substantially affect an individual's health and survival. One route through which this occurs is by altering immune function, which can be highly sensitive to changes in the social environment. However, we currently have limited understanding of how sociality influences markers of immunity in naturalistic populations where social dynamics can be fully realized. To address this gap, we asked if social integration and social status in free-ranging rhesus macaques (Macaca mulatta) predict anatomical and physiological markers of immunity. We used data on agonistic interactions to determine social status, and social network analysis of grooming interactions to generate measures of individual variation in social integration. As measures of immunity, we included the size of two of the major organs involved in the immune response, the spleen and liver, and counts of three types of blood cells (red blood cells, platelets, and white blood cells). Controlling for body mass and age, we found that neither social status nor social integration predicted the size of anatomical markers of immunity. However, individuals that were more socially connected, i.e., with more grooming partners, had lower numbers of white blood cells than their socially isolated counterparts, indicating lower levels of inflammation with increasing levels of integration. These results build upon and extend our knowledge of the relationship between sociality and the immune system in humans and captive animals to free-ranging primates, demonstrating generalizability of the beneficial role of social integration on health.
dc.relation.ispartofPhysiology & Behavioren
dc.rightsCopyright © 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (
dc.subjectSocial networksen
dc.subjectRhesus macaquesen
dc.subjectQL Zoologyen
dc.titleSociality predicts individual variation in the immunity of free-ranging rhesus macaquesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record