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dc.contributor.authorGurung, Suman C.
dc.contributor.authorDixit, Kritika
dc.contributor.authorPaudel, Rajan
dc.contributor.authorSah, Manoj K.
dc.contributor.authorPandit, Ram N.
dc.contributor.authorAryal, Tara P.
dc.contributor.authorKhatiwada, Shikha U.
dc.contributor.authorMajhi, Govind
dc.contributor.authorDhital, Raghu
dc.contributor.authorPaudel, Puskar R.
dc.contributor.authorShrestha, Gyanendra
dc.contributor.authorRai, Bhola
dc.contributor.authorBudhathoki, Gangaram
dc.contributor.authorKhanal, Mukti
dc.contributor.authorMishra, Gokul
dc.contributor.authorLevy, Jens
dc.contributor.authorVan de Rest, Job
dc.contributor.authorThapa, Anchal
dc.contributor.authorRamsay, Andrew
dc.contributor.authorSquire, Stephen B.
dc.contributor.authorLönnroth, Knut
dc.contributor.authorBasnyat, Buddha
dc.contributor.authorCaws, Maxine
dc.identifier.citationGurung , S C , Dixit , K , Paudel , R , Sah , M K , Pandit , R N , Aryal , T P , Khatiwada , S U , Majhi , G , Dhital , R , Paudel , P R , Shrestha , G , Rai , B , Budhathoki , G , Khanal , M , Mishra , G , Levy , J , Van de Rest , J , Thapa , A , Ramsay , A , Squire , S B , Lönnroth , K , Basnyat , B & Caws , M 2023 , ' Comparing additionality of tuberculosis cases using GeneXpert or smear-based active TB case-finding strategies among social contacts of index cases in Nepal ' , Tropical Medicine and Infectious Disease , vol. 8 , no. 7 , 369 .
dc.identifier.otherRIS: urn:C45313C6F7D375D5626261021A534FB8
dc.descriptionFunding: The study obtained funding from European Union, Horizon 2020—IMPACT TB project (grant number: 733174).en
dc.description.abstractThis study compares the yield and additionality of community-based active tuberculosis (TB) active case-finding strategies using either smear microscopy or GeneXpert as the TB diagnostic test. Active case-finding strategies screened social contacts of index cases and high-risk groups in four districts of Nepal in July 2017–2019. Two districts (Chitwan and Dhanusha) applied GeneXpert testing and two districts (Makwanpur and Mahotarri) used smear microscopy. Two control districts implemented standard national TB program activities. Districts implementing GeneXpert testing screened 23,657 people for TB, tested 17,114 and diagnosed 764 TB cases, producing a yield of 4.5%. Districts implementing smear microscopy screened 19,961 people for TB, tested 13,285 and diagnosed 437 cases, producing a yield of 3.3%. The screening numbers required were 31 for GeneXpert and 45.7 for smear districts. The test numbers required were 22.4 and 30.4 for GeneXpert and smear. Using the TB REACH additionality method, social contact tracing for TB through GeneXpert testing contributed to a 20% (3958/3322) increase in district-level TB notifications, smear microscopy 12.4% (3146/2798), and −0.5% (2553/2566) for control districts. Therefore, social contact tracing of TB index cases using GeneXpert testing should be implemented throughout Nepal within the TB FREE initiative to close the notification gap and accelerate progress toward END TB strategy targets.
dc.relation.ispartofTropical Medicine and Infectious Diseaseen
dc.subjectActive case-findingen
dc.subjectTB yield rateen
dc.subjectACF interventionsen
dc.subjectQR Microbiologyen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleComparing additionality of tuberculosis cases using GeneXpert or smear-based active TB case-finding strategies among social contacts of index cases in Nepalen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.description.statusPeer revieweden

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