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Selection on the fly : short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura
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dc.contributor.author | Barata, Carolina | |
dc.contributor.author | Snook, Rhonda R | |
dc.contributor.author | Ritchie, Michael G | |
dc.contributor.author | Kosiol, Carolin | |
dc.date.accessioned | 2023-07-06T11:30:03Z | |
dc.date.available | 2023-07-06T11:30:03Z | |
dc.date.issued | 2023-07-04 | |
dc.identifier | 290046739 | |
dc.identifier | 103a2b8c-0a60-4af2-88fe-b2d2c9e0c041 | |
dc.identifier | 37341535 | |
dc.identifier | 85164246128 | |
dc.identifier.citation | Barata , C , Snook , R R , Ritchie , M G & Kosiol , C 2023 , ' Selection on the fly : short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura ' , Genome Biology and Evolution , vol. 15 , no. 7 , evad113 . https://doi.org/10.1093/gbe/evad113 | en |
dc.identifier.issn | 1759-6653 | |
dc.identifier.other | RIS: urn:0D5DAA88EE65D8B00E336A7F5E1BA4EA | |
dc.identifier.other | ORCID: /0000-0001-7913-8675/work/138327337 | |
dc.identifier.uri | https://hdl.handle.net/10023/27902 | |
dc.description | Funding: This work was supported by the Vienna Science and Technology Fund (WWTF) (10.47379/MA16061). C.K. received funding from the Royal Society (RG170315) and the Carnegie Trust (RIG007474). M.G.R. and R.R.S. have been supported by NERC (UK) grants NE/I014632/1 and NE/V001566/1. Bioinformatics analyses were performed on the computer cluster at the University of St Andrews Bioinformatics Unit, which is funded by Wellcome Trust ISSF awards 105621/Z/14/Z. Complementary data parsing was carried out with the computational resources provided by the Research/Scientific Computing teams at The James Hutton Institute and the National Institute of Agricultural Botany (NIAB)—UK’s Crop Diversity Bioinformatics HPC, BBSRC grant BB/S019669/1. | en |
dc.description.abstract | Experimental evolution studies are powerful approaches to examine the evolutionary history of lab populations. Such studies have shed light on how selection changes phenotypes and genotypes. Most of these studies have not examined the time course of adaptation under sexual selection manipulation, by resequencing the populations’ genomes at multiple time points. Here, we analyze allele frequency trajectories in Drosophila pseudoobscura where we altered their sexual selection regime for 200 generations and sequenced pooled populations at 5 time points. The intensity of sexual selection was either relaxed in monogamous populations (M) or elevated in polyandrous lines (E). We present a comprehensive study of how selection alters population genetics parameters at the chromosome and gene level. We investigate differences in the effective population size—Ne—between the treatments, and perform a genome-wide scan to identify signatures of selection from the time-series data. We found genomic signatures of adaptation to both regimes in D. pseudoobscura. There are more significant variants in E lines as expected from stronger sexual selection. However, we found that the response on the X chromosome was substantial in both treatments, more pronounced in E and restricted to the more recently sex-linked chromosome arm XR in M. In the first generations of experimental evolution, we estimate Ne to be lower on the X in E lines, which might indicate a swift adaptive response at the onset of selection. Additionally, the third chromosome was affected by elevated polyandry whereby its distal end harbors a region showing a strong signal of adaptive evolution especially in E lines. | |
dc.format.extent | 18 | |
dc.format.extent | 2383092 | |
dc.language.iso | eng | |
dc.relation.ispartof | Genome Biology and Evolution | en |
dc.subject | Genomics | en |
dc.subject | Sexual selection | en |
dc.subject | Experimental evolution | en |
dc.subject | Time series | en |
dc.subject | Pooled sequencing | en |
dc.subject | QH426 Genetics | en |
dc.subject | DAS | en |
dc.subject | MCC | en |
dc.subject.lcc | QH426 | en |
dc.title | Selection on the fly : short-term adaptation to an altered sexual selection regime in Drosophila pseudoobscura | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.sponsor | Carnegie Trust | en |
dc.contributor.sponsor | NERC | en |
dc.contributor.sponsor | NERC | en |
dc.contributor.sponsor | The Wellcome Trust | en |
dc.contributor.institution | University of St Andrews. University of St Andrews | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Centre for Biological Diversity | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. St Andrews Bioinformatics Unit | en |
dc.identifier.doi | 10.1093/gbe/evad113 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | RG170315 | en |
dc.identifier.grantnumber | RIG007474 | en |
dc.identifier.grantnumber | NE/I014632/1 | en |
dc.identifier.grantnumber | NE/V001566/1 | en |
dc.identifier.grantnumber | 105621/Z/14/Z | en |
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