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dc.contributor.authorOgilvie, Charlene Elizabeth
dc.contributor.authorMelo Czekster, Clarissa
dc.date.accessioned2023-06-30T11:30:05Z
dc.date.available2023-06-30T11:30:05Z
dc.date.issued2023-07-15
dc.identifier287446085
dc.identifierd5b956a2-3243-4ff8-87ac-b36cf013f68f
dc.identifier001025440600001
dc.identifier85162146863
dc.identifier37343497
dc.identifier001025440600001
dc.identifier.citationOgilvie , C E & Melo Czekster , C 2023 , ' Cyclic dipeptides and the human microbiome : opportunities and challenges ' , Bioorganic & Medicinal Chemistry , vol. 90 , 117372 . https://doi.org/10.1016/j.bmc.2023.117372en
dc.identifier.issn0968-0896
dc.identifier.urihttps://hdl.handle.net/10023/27862
dc.descriptionFunding: C.M.C. is funded by the Wellcome Trust (210486/Z/18/Z and [204821/Z/16/Z] to the University of St Andrews). C.E.O. is the recipient of a Carnegie Trust PhD studentship (PHD008520).en
dc.description.abstractResearch into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.
dc.format.extent6
dc.format.extent3650560
dc.language.isoeng
dc.relation.ispartofBioorganic & Medicinal Chemistryen
dc.subjectMicrobiomeen
dc.subjectCyclic dipeptideen
dc.subjectDiketopiperazineen
dc.subjectHost-pathogen interactionen
dc.subjectQD Chemistryen
dc.subjectQH301 Biologyen
dc.subjectT-NDASen
dc.subjectMCCen
dc.subject.lccQDen
dc.subject.lccQH301en
dc.titleCyclic dipeptides and the human microbiome : opportunities and challengesen
dc.typeJournal itemen
dc.contributor.sponsorThe Wellcome Trusten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1016/j.bmc.2023.117372
dc.description.statusPeer revieweden
dc.identifier.grantnumberen


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