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The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart
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dc.contributor.author | Dorward, Amy Marie | |
dc.contributor.author | Stewart, Alan J. | |
dc.contributor.author | Pitt, Samantha J. | |
dc.date.accessioned | 2023-06-28T15:30:07Z | |
dc.date.available | 2023-06-28T15:30:07Z | |
dc.date.issued | 2023-06-16 | |
dc.identifier | 286210089 | |
dc.identifier | 6041eeea-b06c-483c-935c-a9775985f3d3 | |
dc.identifier | 85163273984 | |
dc.identifier.citation | Dorward , A M , Stewart , A J & Pitt , S J 2023 , ' The role of Zn 2+ in shaping intracellular Ca 2+ dynamics in the heart ' , Journal of General Physiology , vol. 155 , no. 7 , e202213206 . https://doi.org/10.1085/jgp.202213206 | en |
dc.identifier.issn | 0022-1295 | |
dc.identifier.other | ORCID: /0000-0002-8504-4234/work/137088941 | |
dc.identifier.other | ORCID: /0000-0003-2257-1595/work/137089032 | |
dc.identifier.other | ORCID: /0000-0003-4580-1840/work/137089268 | |
dc.identifier.uri | https://hdl.handle.net/10023/27831 | |
dc.description | Funding: This work was supported by the British Heart Foundation (grant code: PG/21/10468, FS/19/69/34639) and the Biotechnological and Biological Sciences Research Council (grant code: BB/V014684/1). | en |
dc.description.abstract | Increasing evidence suggests that Zn2+ acts as a second messenger capable of transducing extracellular stimuli into intracellular signalling events. The importance of Zn2+ as a signalling molecule in cardiovascular functioning is gaining traction. In the heart, Zn2+ plays important roles in excitation-contraction (EC) coupling, excitation-transcription coupling, and cardiac ventricular morphogenesis. Zn2+ homeostasis in cardiac tissue is tightly regulated through the action of a combination of transporters, buffers and sensors. Zn2+-mishandling is a common feature of various cardiovascular diseases. However, the precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during normal cardiac function and during pathological conditions are not fully understood. In this review we consider the major pathways by which the concentration of intracellular Zn2+ is regulated in the heart, the role of Zn2+ in EC coupling and discuss how Zn2+-dyshomeostasis resulting from altered expression levels and efficacy of Zn2+ regulatory proteins are key drivers in the progression of cardiac dysfunction. | |
dc.format.extent | 18 | |
dc.format.extent | 2151897 | |
dc.format.extent | 4679796 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of General Physiology | en |
dc.subject | RC Internal medicine | en |
dc.subject | T-NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | MCC | en |
dc.subject.lcc | RC | en |
dc.title | The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart | en |
dc.type | Journal article | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | https://doi.org/10.1085/jgp.202213206 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | BB/V014684/1 | en |
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