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dc.contributor.authorIbrahim, Ahmed B. M.
dc.contributor.authorMahmoud, Ghada Abd-Elmonsef
dc.contributor.authorCordes, David B.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.identifier.citationIbrahim , A B M , Mahmoud , G A-E , Cordes , D B & Slawin , A M Z 2022 , ' Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system ' , Applied Organometallic Chemistry , vol. 36 , no. 8 , e6798 .
dc.identifier.otherPURE: 280215665
dc.identifier.otherPURE UUID: 49aa8e8b-1bc3-43cd-bc9f-480e99079d53
dc.identifier.otherRIS: urn:88A0C6B24A7D23263F58B2B68040655C
dc.identifier.otherORCID: /0000-0002-9527-6418/work/115630955
dc.identifier.otherORCID: /0000-0002-5366-9168/work/115631010
dc.identifier.otherScopus: 85132929175
dc.identifier.otherWOS: 000817787800001
dc.description.abstractPb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1 , [Pb(L2)2] 2 , [Hg(L1)2] 3 and [Hg(L2)2] 4 ; HL 1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL 2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.
dc.relation.ispartofApplied Organometallic Chemistryen
dc.rightsCopyright © 2022 John Wiley & Sons Ltd.This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectNNS ligandsen
dc.subjectHeavy metalsen
dc.subjectSuperoxide dismutaseen
dc.subjectQD Chemistryen
dc.titlePb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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