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dc.contributor.authorIbrahim, Ahmed B. M.
dc.contributor.authorMahmoud, Ghada Abd-Elmonsef
dc.contributor.authorCordes, David B.
dc.contributor.authorSlawin, Alexandra M. Z.
dc.date.accessioned2023-06-27T23:39:10Z
dc.date.available2023-06-27T23:39:10Z
dc.date.issued2022-07-12
dc.identifier280215665
dc.identifier49aa8e8b-1bc3-43cd-bc9f-480e99079d53
dc.identifier85132929175
dc.identifier000817787800001
dc.identifier.citationIbrahim , A B M , Mahmoud , G A-E , Cordes , D B & Slawin , A M Z 2022 , ' Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system ' , Applied Organometallic Chemistry , vol. 36 , no. 8 , e6798 . https://doi.org/10.1002/aoc.6798en
dc.identifier.issn0268-2605
dc.identifier.otherRIS: urn:88A0C6B24A7D23263F58B2B68040655C
dc.identifier.otherORCID: /0000-0002-9527-6418/work/115630955
dc.identifier.otherORCID: /0000-0002-5366-9168/work/115631010
dc.identifier.urihttps://hdl.handle.net/10023/27814
dc.description.abstractPb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1 , [Pb(L2)2] 2 , [Hg(L1)2] 3 and [Hg(L2)2] 4 ; HL 1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL 2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.
dc.format.extent11
dc.format.extent1528217
dc.language.isoeng
dc.relation.ispartofApplied Organometallic Chemistryen
dc.subjectNNS ligandsen
dc.subjectHeavy metalsen
dc.subjectPathogenen
dc.subjectCatalaseen
dc.subjectSuperoxide dismutaseen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subjectMCCen
dc.subject.lccQDen
dc.titlePb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doi10.1002/aoc.6798
dc.description.statusPeer revieweden
dc.date.embargoedUntil2023-06-28


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