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Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system
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dc.contributor.author | Ibrahim, Ahmed B. M. | |
dc.contributor.author | Mahmoud, Ghada Abd-Elmonsef | |
dc.contributor.author | Cordes, David B. | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.date.accessioned | 2023-06-27T23:39:10Z | |
dc.date.available | 2023-06-27T23:39:10Z | |
dc.date.issued | 2022-07-12 | |
dc.identifier | 280215665 | |
dc.identifier | 49aa8e8b-1bc3-43cd-bc9f-480e99079d53 | |
dc.identifier | 85132929175 | |
dc.identifier | 000817787800001 | |
dc.identifier.citation | Ibrahim , A B M , Mahmoud , G A-E , Cordes , D B & Slawin , A M Z 2022 , ' Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system ' , Applied Organometallic Chemistry , vol. 36 , no. 8 , e6798 . https://doi.org/10.1002/aoc.6798 | en |
dc.identifier.issn | 0268-2605 | |
dc.identifier.other | RIS: urn:88A0C6B24A7D23263F58B2B68040655C | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/115630955 | |
dc.identifier.other | ORCID: /0000-0002-5366-9168/work/115631010 | |
dc.identifier.uri | https://hdl.handle.net/10023/27814 | |
dc.description.abstract | Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1 , [Pb(L2)2] 2 , [Hg(L1)2] 3 and [Hg(L2)2] 4 ; HL 1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL 2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations. | |
dc.format.extent | 11 | |
dc.format.extent | 1528217 | |
dc.language.iso | eng | |
dc.relation.ispartof | Applied Organometallic Chemistry | en |
dc.subject | NNS ligands | en |
dc.subject | Heavy metals | en |
dc.subject | Pathogen | en |
dc.subject | Catalase | en |
dc.subject | Superoxide dismutase | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject | MCC | en |
dc.subject.lcc | QD | en |
dc.title | Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1002/aoc.6798 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2023-06-28 |
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