Temporal dynamics of Na/K pump mediated memory traces : insights from conductance-based models of Drosophila neurons
Abstract
Sodium potassium ATPases (Na/K pumps) mediate long-lasting, dynamic cellular memories that can last tens of seconds. The mechanisms controlling the dynamics of this type of cellular memory are not well understood and can be counterintuitive. Here, we use computational modeling to examine how Na/K pumps and the ion concentration dynamics they influence shape cellular excitability. In a Drosophila larval motor neuron model, we incorporate a Na/K pump, a dynamic intracellular Na+ concentration, and a dynamic Na+ reversal potential. We probe neuronal excitability with a variety of stimuli, including step currents, ramp currents, and zap currents, then monitor the sub- and suprathreshold voltage responses on a range of time scales. We find that the interactions of a Na+-dependent pump current with a dynamic Na+ concentration and reversal potential endow the neuron with rich response properties that are absent when the role of the pump is reduced to the maintenance of constant ion concentration gradients. In particular, these dynamic pump-Na+ interactions contribute to spike rate adaptation and result in long-lasting excitability changes after spiking and even after sub-threshold voltage fluctuations on multiple time scales. We further show that modulation of pump properties can profoundly alter a neuron’s spontaneous activity and response to stimuli by providing a mechanism for bursting oscillations. Our work has implications for experimental studies and computational modeling of the role of Na/K pumps in neuronal activity, information processing in neural circuits, and the neural control of animal behavior.
Citation
Megwa , O F , Pascual , L M , Günay , C , Pulver , S R & Prinz , A A 2023 , ' Temporal dynamics of Na/K pump mediated memory traces : insights from conductance-based models of Drosophila neurons ' , Frontiers in Neuroscience , vol. 17 . https://doi.org/10.3389/fnins.2023.1154549
Publication
Frontiers in Neuroscience
Status
Peer reviewed
ISSN
1662-453XType
Journal article
Rights
Copyright © 2023 Megwa, Pascual, Günay, Pulver and Prinz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Description
Funding: This work was supported by a Royal Society Research Grant to SP (RG150108), Collaborative Research Grant funding by the Halle Institute for Global Research at Emory University and University of St Andrews to SP and AP, a Wellcome Trust Seed Award to SP (105621/Z/14/Z), a Emory Computational Neuroscience Fellowship stipend to OM, support from Emory University’s Graduate Division of Biological and Biomedical Sciences and from the George W. Woodruff Fellowship for LP, and VPASA Seed Grant funding at Georgia Gwinnett College awarded to CG.Collections
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