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Synthesis of complex aryl MIDA boronates by Rh-catalyzed [2+2+2] cycloaddition
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dc.contributor.author | Halford-McGuff, John M. | |
dc.contributor.author | Cordes, David B. | |
dc.contributor.author | Watson, Allan J. B. | |
dc.date.accessioned | 2023-06-04T14:30:02Z | |
dc.date.available | 2023-06-04T14:30:02Z | |
dc.date.issued | 2023-06-25 | |
dc.identifier | 286868733 | |
dc.identifier | 775fa7d9-85f8-40e0-a428-10edae68503e | |
dc.identifier | 85162188886 | |
dc.identifier.citation | Halford-McGuff , J M , Cordes , D B & Watson , A J B 2023 , ' Synthesis of complex aryl MIDA boronates by Rh-catalyzed [2+2+2] cycloaddition ' , Chemical Communications , vol. 59 , no. 50 , pp. 7759-7762 . https://doi.org/10.1039/d3cc00761h | en |
dc.identifier.issn | 1359-7345 | |
dc.identifier.other | Jisc: 1118155 | |
dc.identifier.other | Jisc: 1118155 | |
dc.identifier.other | publisher-id: d3cc00761h | |
dc.identifier.other | ORCID: /0000-0002-5366-9168/work/136288774 | |
dc.identifier.other | ORCID: /0000-0002-1582-4286/work/136289068 | |
dc.identifier.uri | https://hdl.handle.net/10023/27742 | |
dc.description | Funding: J. M. H.-M. thanks the EPSRC Centre for Doctoral Training EaSI-CAT for a PhD studentship. A. J. B. W. thanks the Leverhulme Trust for a Research Fellowship (RF-2022-014) and the EPSRC Programme Grant “Boron: Beyond the Reagent” (EP/W007517/1) for support. | en |
dc.description.abstract | A Rh-catalyzed [2+2+2] cycloaddition approach for the synthesis of BMIDA-functionalized arenes is reported. The developed method overcomes the long-standing reactivity problems associated with internal alkynes and allows access to highly functionalized borylated benzene scaffolds. The method is broadly functional group tolerant and generally high yielding. The utility of the products is demonstrated through elaboration of the BMIDA motif, and in the synthesis of fused heterocycles via intramolecular Chan–Lam etherification and amination. The dominance of sterically controlled reactivity is described. | |
dc.format.extent | 4 | |
dc.format.extent | 1306658 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemical Communications | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject | MCC | en |
dc.subject.lcc | QD | en |
dc.title | Synthesis of complex aryl MIDA boronates by Rh-catalyzed [2+2+2] cycloaddition | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Leverhulme Trust | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.identifier.doi | 10.1039/d3cc00761h | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | RF-2022-014 | en |
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