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Comparison of Lymphocyte-CRP ratio to conventional inflammatory markers for predicting clinical outcomes in COVID-19
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dc.contributor.author | Liu, Alexander Qichen | |
dc.contributor.author | Hammond, Robert | |
dc.contributor.author | Chan, Kenneth | |
dc.contributor.author | Chukwuenweniwe, Chukwugozie | |
dc.contributor.author | Johnson, Rebecca | |
dc.contributor.author | Khair, Duaa | |
dc.contributor.author | Duck, Eleanor | |
dc.contributor.author | Olubodun, Oluwaseun | |
dc.contributor.author | Barwick, Kristian | |
dc.contributor.author | Banya, Winston | |
dc.contributor.author | Stirrup, James | |
dc.contributor.author | Donnelly, Peter Duncan | |
dc.contributor.author | Kaski, Juan Carlos | |
dc.contributor.author | Coates, Anthony R | |
dc.date.accessioned | 2023-05-29T11:30:21Z | |
dc.date.available | 2023-05-29T11:30:21Z | |
dc.date.issued | 2023-05-29 | |
dc.identifier | 286657014 | |
dc.identifier | f66b9358-85ab-42fc-bdc0-d2616913ba91 | |
dc.identifier | 85163630573 | |
dc.identifier.citation | Liu , A Q , Hammond , R , Chan , K , Chukwuenweniwe , C , Johnson , R , Khair , D , Duck , E , Olubodun , O , Barwick , K , Banya , W , Stirrup , J , Donnelly , P D , Kaski , J C & Coates , A R 2023 , ' Comparison of Lymphocyte-CRP ratio to conventional inflammatory markers for predicting clinical outcomes in COVID-19 ' , Journal of Personalized Medicine , vol. 13 , no. 6 , 909 . https://doi.org/10.3390/jpm13060909 | en |
dc.identifier.issn | 2075-4426 | |
dc.identifier.other | ORCID: /0000-0003-3664-3641/work/157140944 | |
dc.identifier.uri | https://hdl.handle.net/10023/27695 | |
dc.description.abstract | Background : In COVID-19 patients, lymphocyte–CRP ratio (LCR) is a promising biomarker for predicting adverse clinical outcomes. How well LCR performs compared to conventional inflammatory markers for prognosticating COVID-19 patients remains unclear, which hinders the clinical translation of this novel biomarker. Methods : In a cohort of COVID-19 inpatients, we characterised the clinical applicability of LCR by comparing its prognostic value against conventional inflammatory markers for predicting inpatient mortality and a composite of mortality, invasive/non-invasive ventilation and intensive care unit admissions. Results : Of the 413 COVID-19 patients, 100 (24%) patients suffered inpatient mortality. On Receiver Operating Characteristics analysis, LCR performed similarly to CRP for predicting mortality (AUC 0.74 vs. 0.71, p = 0.049) and the composite endpoint (AUC 0.76 vs. 0.76, p = 0.812). LCR outperformed lymphocyte counts (AUC 0.74 vs. 0.66, p = 0.002), platelet counts (AUC 0.74 vs. 0.61, p = 0.003) and white cell counts (AUC 0.74 vs. 0.54, p < 0.001) for predicting mortality. On Kaplan–Meier analysis, patients with a low LCR (below a 58 cut-off) had worse inpatient survival than patients with other LCR values (p < 0.001). Conclusion : LCR appears comparable to CRP, but outperformed other inflammatory markers, for prognosticating COVID-19 patients. Further studies are required to improve the diagnostic value of LCR to facilitate clinical translation. | |
dc.format.extent | 11 | |
dc.format.extent | 2908032 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Personalized Medicine | en |
dc.subject | Lymphocyte–CRP ratio | en |
dc.subject | Coronavirus disease 19 | en |
dc.subject | C-reactive protein | en |
dc.subject | Risk stratification | en |
dc.subject | Prognostic risk | en |
dc.subject | COVID-19 | en |
dc.subject | QR355 Virology | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | NDAS | en |
dc.subject | MCC | en |
dc.subject.lcc | QR355 | en |
dc.subject.lcc | RA0421 | en |
dc.title | Comparison of Lymphocyte-CRP ratio to conventional inflammatory markers for predicting clinical outcomes in COVID-19 | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.identifier.doi | https://doi.org/10.3390/jpm13060909 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.mdpi.com/2075-4426/13/6/909 | en |
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