Synthesis and Wittig rearrangement of 3- and 4-benzyloxyphenylphosphonamidates
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A series of seven O-ethyl-N-butylphenylphosphonamidates with benzyl ether substituents at the para or meta position have been prepared and fully characterised. Upon treatment with n-butyllithium in THF at RT, these undergo Wittig rearrangement in six cases to give the novel phosphonamidate-substituted diarylmethanols in moderate to good yield.
Aitken , R A & Inwood , R A 2023 , ' Synthesis and Wittig rearrangement of 3- and 4-benzyloxyphenylphosphonamidates ' , Organics , vol. 4 , no. 1 , pp. 59-69 . https://doi.org/10.3390/org4010005
Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).
DescriptionFunding: We thank EPSRC(UK) and CRITICAT Centre for Doctoral Training for a studentship to R.A.I. (Grant EP/L016419/1).
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