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Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons

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Allodi_2021_NC_Locomotor_deficits_CC.pdf (8.778Mb)
Date
31/05/2021
Author
Allodi, Ilary
Montañana-Rosell, Roser
Selvan, Raghavendra
Löw, Peter
Kiehn, Ole
Keywords
Amyotrophic Lateral Sclerosis (ALS)/genetics
Animals
Disease Models, Animal
Female
Homeodomain Proteins/metabolism
Humans
Interneurons/pathology
Locomotion/physiology
Male
Mice
Mice, Transgenic
Motor Neurons/pathology
Muscle Fibers, Fast-Twitch/physiology
Neuromuscular Junction/pathology
Spinal Cord/cytology
Superoxide Dismutase/genetics
Superoxide Dismutase-1/genetics
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
QH426 Genetics
DAS
MCC
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Abstract
ALS is characterized by progressive inability to execute movements. Motor neurons innervating fast-twitch muscle-fibers preferentially degenerate. The reason for this differential vulnerability and its consequences on motor output is not known. Here, we uncover that fast motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression in the SOD1G93A mouse model leads to specific loss of inhibitory synapses onto fast motor neurons. Inhibitory V1 interneurons show similar innervation pattern and loss of synapses. Moreover, from postnatal day 63, there is a loss of V1 interneurons in the SOD1G93A mouse. The V1 interneuron degeneration appears before motor neuron death and is paralleled by the development of a specific locomotor deficit affecting speed and limb coordination. This distinct ALS-induced locomotor deficit is phenocopied in wild-type mice but not in SOD1G93A mice after appearing of the locomotor phenotype when V1 spinal interneurons are silenced. Our study identifies a potential source of non-autonomous motor neuronal vulnerability in ALS and links ALS-induced changes in locomotor phenotype to inhibitory V1-interneurons.
Citation
Allodi , I , Montañana-Rosell , R , Selvan , R , Löw , P & Kiehn , O 2021 , ' Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons ' , Nature Communications , vol. 12 , 3251 . https://doi.org/10.1038/s41467-021-23224-7
Publication
Nature Communications
Status
Peer reviewed
DOI
https://doi.org/10.1038/s41467-021-23224-7
ISSN
2041-1723
Type
Journal article
Rights
Copyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Description
Funding: This work was supported by the Lundbeck Foundation (I.A.), the Björklund foundation (I.A.), the A.P. Møller foundation (I.A.), the Novo Nordisk Laureate Program (O.K., NNF15OC0014186), The Lundbeck Foundation (O.K.), the Louis-Hansen foundation (R.M.R.) and The Faculty of Health and Medical Sciences (O.K.).
Collections
  • University of St Andrews Research
URI
http://hdl.handle.net/10023/26846

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