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dc.contributor.authorVacher, Marissa C.
dc.contributor.authorDurrant, Claire S.
dc.contributor.authorRose, Jamie
dc.contributor.authorHall, Ailsa J.
dc.contributor.authorSpires-Jones, Tara L.
dc.contributor.authorGunn-Moore, Frank
dc.contributor.authorDagleish, Mark P.
dc.date.accessioned2023-01-06T12:30:05Z
dc.date.available2023-01-06T12:30:05Z
dc.date.issued2023-04-01
dc.identifier282566255
dc.identifier44fe2dc2-217f-45ab-8d85-f82cdc093820
dc.identifier85145330760
dc.identifier000906026200001
dc.identifier.citationVacher , M C , Durrant , C S , Rose , J , Hall , A J , Spires-Jones , T L , Gunn-Moore , F & Dagleish , M P 2023 , ' Alzheimer’s disease-like neuropathology in three species of oceanic dolphin ' , European Journal of Neuroscience , vol. 57 , no. 7 , pp. 1161-1179 . https://doi.org/10.1111/ejn.15900en
dc.identifier.issn0953-816X
dc.identifier.otherRIS: urn:4698B2B22C6E0BB094A318AE8351997A
dc.identifier.otherORCID: /0000-0002-7562-1771/work/126031277
dc.identifier.otherORCID: /0000-0003-3422-3387/work/126031424
dc.identifier.urihttps://hdl.handle.net/10023/26699
dc.descriptionFunding: This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. MCV was supported, in part, by the Erasmus+ mobility program. CD is a Race Against Dementia Dyson Fellow and Emerging Leader at the UK Dementia Research Institute. JR is supported by the UK Dementia Research Institute. AJH was funded by the Natural Environment Research Council (Grant No. NE/R015007/1). TS-J is supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 681181) and the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society, and Alzheimer’s Research UK. FG-M is supported by the RSMacDonald Charitable Trust, Rosetrees Trust and the EPSRC programme grant EP/P030017/1. MPD was funded by the Scottish Government and undertakes the detailed histological examination of cetacean tissues for SMASS which is supported by Marine Scotland, a division of the Scottish Government, and the Department for Environment, Food and Rural Affairs (defra), a department of the United Kingdom Government.en
dc.description.abstractAlzheimer's disease (AD) is the most common neurodegenerative disease and the primary cause of disability and dependency among elderly humans worldwide. AD is thought to be a disease unique to humans although several other animals develop some aspects of AD-like pathology. Odontocetes (toothed whales) share traits with humans that suggest they may be susceptible to AD. The brains of 22 stranded odontocetes of five different species were examined using immunohistochemistry to investigate the presence or absence of neuropathological hallmarks of AD: amyloid-beta plaques, phospho-tau accumulation and gliosis. Immunohistochemistry revealed that all aged animals accumulated amyloid plaque pathology. In three animals of three different species of odontocete, there was co-occurrence of amyloid-beta plaques, intraneuronal accumulation of hyperphosphorylated tau, neuropil threads and neuritic plaques. One animal showed well-developed neuropil threads, phospho-tau accumulation and neuritic plaques, but no amyloid plaques. Microglia and astrocytes were present as expected in all brain samples examined, but we observed differences in cell morphology and numbers between individual animals. The simultaneous occurrence of amyloid-beta plaques and hyperphosphorylated tau pathology in the brains of odontocetes shows that these three species develop AD-like neuropathology spontaneously. The significance of this pathology with respect to the health and, ultimately, death of the animals remains to be determined. However, it may contribute to the cause(s) of unexplained live-stranding in some odontocete species and supports the 'sick-leader' theory whereby healthy conspecifics in a pod mass strand due to high social cohesion.
dc.format.extent19
dc.format.extent5231532
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Neuroscienceen
dc.subjectTauen
dc.subjectNeurofibrillary tanglesen
dc.subjectAmyloid plaquesen
dc.subjectBeta amyloiden
dc.subjectImmunohistochemistryen
dc.subjectCetaceanen
dc.subjectOdontocetesen
dc.subjectQH301 Biologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject3rd-DASen
dc.subjectMCCen
dc.subject.lccQH301en
dc.subject.lccRC0321en
dc.titleAlzheimer’s disease-like neuropathology in three species of oceanic dolphinen
dc.typeJournal articleen
dc.contributor.sponsorNERCen
dc.contributor.sponsorEPSRCen
dc.contributor.sponsorRosetrees Trusten
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Sea Mammal Research Uniten
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1111/ejn.15900
dc.description.statusPeer revieweden
dc.identifier.grantnumberNE/R015007/1en
dc.identifier.grantnumberEP/P030017/1en
dc.identifier.grantnumberA1163en


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