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Mapping HPV 16 sub-lineages in anal cancer and implications for disease outcomes
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dc.contributor.author | Guerendiain, Daniel | |
dc.contributor.author | Arroyo-Mühr, Laila Sara | |
dc.contributor.author | Grigorescu, Raluca | |
dc.contributor.author | Holden, Matthew | |
dc.contributor.author | Cuschieri, Kate | |
dc.date.accessioned | 2022-12-20T10:30:06Z | |
dc.date.available | 2022-12-20T10:30:06Z | |
dc.date.issued | 2022-12-19 | |
dc.identifier | 282550449 | |
dc.identifier | 2bc02484-a211-4dae-a6b6-b679a2995e09 | |
dc.identifier | 85144858053 | |
dc.identifier | 000900567400001 | |
dc.identifier.citation | Guerendiain , D , Arroyo-Mühr , L S , Grigorescu , R , Holden , M & Cuschieri , K 2022 , ' Mapping HPV 16 sub-lineages in anal cancer and implications for disease outcomes ' , Diagnostics , vol. 12 , no. 12 , 322 . https://doi.org/10.3390/diagnostics12123222 | en |
dc.identifier.issn | 2075-4418 | |
dc.identifier.other | ORCID: /0000-0002-7536-1308/work/125303198 | |
dc.identifier.other | ORCID: /0000-0002-4958-2166/work/125303270 | |
dc.identifier.uri | https://hdl.handle.net/10023/26629 | |
dc.description.abstract | The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential. In other cancers associated with human papillomavirus (HPV), HPV 16 sub-lineages have been shown to be associated with disease status and prognosis. However, in anal cancer, they have been under-explored. A total of 119 HPV 16-positive anal cancer lesions diagnosed between 2009 and 2018 in Scotland and 134 HPV 16-positive residual rectal swabs from asymptomatic men collected in 2016/7 were whole genome sequenced. The association of HPV 16 sub-lineages with underlying disease status (cancer vs. asymptomatic) and overall survival in anal cancer samples was assessed (comparing A1 vs non-A1 sub-lineages). A1 was the dominant sub-lineage present in the anal cancer (76.5%) and the asymptomatic (76.1%) cohorts. A2 was the second most dominant sub-lineage in both groups (16.8% and 17.2%, respectively). We did not observe significant associations of sub-lineage with demographics, clinical variables or survival (A1 vs. non-A1 sub-lineages (HR 0.83, 0.28–2.46 p = 0.743)). HPV 16 sub-lineages do to not appear to cluster with disease vs asymptomatic carriage or be independently associated with outcomes in anal cancer patients. Further international studies on anal HPV sub-lineage mapping will help to determine whether this is a consistent observation. | |
dc.format.extent | 12 | |
dc.format.extent | 745052 | |
dc.language.iso | eng | |
dc.relation.ispartof | Diagnostics | en |
dc.subject | Human papillomavirus | en |
dc.subject | HPV 16 sub-lineages | en |
dc.subject | Anal cancer | en |
dc.subject | QH426 Genetics | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | DAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject | MCC | en |
dc.subject.lcc | QH426 | en |
dc.subject.lcc | RC0254 | en |
dc.title | Mapping HPV 16 sub-lineages in anal cancer and implications for disease outcomes | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. Infection and Global Health Division | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. St Andrews Bioinformatics Unit | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.3390/diagnostics12123222 | |
dc.description.status | Peer reviewed | en |
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