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Cyclic nucleotide signaling in phage defense and counter-defense
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dc.contributor.author | Athukoralage, Januka S. | |
dc.contributor.author | White, Malcolm F. | |
dc.date.accessioned | 2022-12-07T13:30:04Z | |
dc.date.available | 2022-12-07T13:30:04Z | |
dc.date.issued | 2022-09 | |
dc.identifier | 279616848 | |
dc.identifier | 09cd1bac-7d7c-4dc4-b3cd-75c05df703df | |
dc.identifier | 35567297 | |
dc.identifier | 000863509300024 | |
dc.identifier | 85132231185 | |
dc.identifier.citation | Athukoralage , J S & White , M F 2022 , ' Cyclic nucleotide signaling in phage defense and counter-defense ' , Annual Review of Virology , vol. 9 , pp. 451-468 . https://doi.org/10.1146/annurev-virology-100120-010228 | en |
dc.identifier.issn | 2327-056X | |
dc.identifier.other | RIS: urn:DF3699F59C0DD0767391B845673CE635 | |
dc.identifier.other | ORCID: /0000-0003-1543-9342/work/113399093 | |
dc.identifier.uri | https://hdl.handle.net/10023/26554 | |
dc.description | Work on cyclic nucleotide signaling in the authors’ lab is supported by the Biotechnology and Biological Sciences Research Council (ref. BB/S000313 and BB/T004789) and a European Research Council Advanced Grant (grant 101018608). J.S.A. is supported by a European Molecular Biology Organization long-term fellowship (ALTF 1201-2020). | en |
dc.description.abstract | Advances in our understanding of prokaryotic antiphage defense mechanisms in the past few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a crucial role in switching infected cells into an antiviral state. Defense pathways including type III CRISPR (clustered regularly interspaced palindromic repeats), CBASS (cyclic nucleotide-based antiphage signaling system), PYCSAR (pyrimidine cyclase system for antiphage resistance), and Thoeris all use cyclic nucleotides as second messengers to activate a diverse range of effector proteins. These effectors typically degrade or disrupt key cellular components such as nucleic acids, membranes, or metabolites, slowing down viral replication kinetics at great cost to the infected cell. Mechanisms to manipulate the levels of cyclic nucleotides are employed by cells to regulate defense pathways and by viruses to subvert them. Here we review the discovery and mechanism of the key pathways, signaling molecules and effectors, parallels and differences between the systems, open questions, and prospects for future research in this area. | |
dc.format.extent | 18 | |
dc.format.extent | 3439889 | |
dc.language.iso | eng | |
dc.relation.ispartof | Annual Review of Virology | en |
dc.subject | CRISPR | en |
dc.subject | CBASS | en |
dc.subject | Antiviral defense | en |
dc.subject | Cyclic nucleotide | en |
dc.subject | Abortive infection | en |
dc.subject | QR355 Virology | en |
dc.subject | T-NDAS | en |
dc.subject | AC | en |
dc.subject.lcc | QR355 | en |
dc.title | Cyclic nucleotide signaling in phage defense and counter-defense | en |
dc.type | Journal article | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.sponsor | BBSRC | en |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.institution | University of St Andrews. St Andrews Bioinformatics Unit | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | 10.1146/annurev-virology-100120-010228 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | BB/S000313/1 | en |
dc.identifier.grantnumber | BB/T004789/1 | en |
dc.identifier.grantnumber | 01018608 | en |
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