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dc.contributor.authorZhou, Liang
dc.contributor.authorLei, Qi
dc.contributor.authorGuo, Jimin
dc.contributor.authorGao, Yuanyuan
dc.contributor.authorShi, Jianjun
dc.contributor.authorYu, Hong
dc.contributor.authorYin, Wenxiang
dc.contributor.authorCao, Jiangfan
dc.contributor.authorXiao, Botao
dc.contributor.authorAndreo, Jacopo
dc.contributor.authorEttlinger, Romy
dc.contributor.authorJeffrey Brinker, C
dc.contributor.authorWuttke, Stefan
dc.contributor.authorZhu, Wei
dc.identifier.citationZhou , L , Lei , Q , Guo , J , Gao , Y , Shi , J , Yu , H , Yin , W , Cao , J , Xiao , B , Andreo , J , Ettlinger , R , Jeffrey Brinker , C , Wuttke , S & Zhu , W 2022 , ' Long-term whole blood DNA preservation by cost-efficient cryosilicification ' , Nature Communications , vol. 13 , 6265 .
dc.identifier.otherPURE: 282006267
dc.identifier.otherPURE UUID: ef90b747-f844-4901-b663-c7f2e39e35a8
dc.identifier.otherJisc: 702135
dc.identifier.otherPubMed: 36270991
dc.identifier.otherpii: 10.1038/s41467-022-33759-y
dc.identifier.otherpmc: PMC9587218
dc.identifier.otherScopus: 85140297991
dc.identifier.otherWOS: 000871124000043
dc.descriptionFunding: This work was supported by the National Natural Science Foundation of China (21972047 to W.Z., 52003086 to Q.L.), Guangdong Provincial Pearl River Talents Program (2019QN01Y314 to Q.L.), the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08Y318 to W.Z.), Natural Science Foundation of Guangdong Province, China (2021A1515010724 to Q.L.), China Postdoctoral Science Foundation (2020M672625, 2021T140213 to Q.L.), Science and Technology Project of Guangzhou, China (202102020352 to W.Z., 202102020259 to Q.L.), the Fundamental Research Funds for the Central Universities of China. The authors thank the support from the Guangzhou Women and Children’s Medical Center and Laboratory Animal Research Center of the South China University of Technology. S.W. acknowledges funding from the Basque Government Industry Department under the ELKARTEK and HAZITEK programs.en
dc.description.abstractDeoxyribonucleic acid (DNA) is the blueprint of life, and cost-effective methods for its long-term storage could have many potential benefits to society. Here we present the method of in situ cryosilicification of whole blood cells, which allows long-term preservation of DNA. Importantly, our straightforward approach is inexpensive, reliable, and yields cryosilicified samples that fulfill the essential criteria for safe, long-term DNA preservation, namely robustness against external stressors, such as radical oxygen species or ultraviolet radiation, and long-term stability in humid conditions at elevated temperatures. Our approach could enable the room temperature storage of genomic information in book-size format for more than one thousand years (thermally equivalent), costing only 0.5 $/person. Additionally, our demonstration of 3D-printed DNA banking artefacts, could potentially allow 'artificial fossilization'.
dc.relation.ispartofNature Communicationsen
dc.rightsCopyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.subjectPreservation, Biological - methodsen
dc.subjectBlood Preservation - methodsen
dc.subjectUltraviolet Raysen
dc.subjectDNA - geneticsen
dc.subjectQH426 Geneticsen
dc.titleLong-term whole blood DNA preservation by cost-efficient cryosilicificationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.description.statusPeer revieweden

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