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Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4'-fluoroadenosine is identified as a co-product
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dc.contributor.author | Chen, Yawen | |
dc.contributor.author | Zhang, Qingzhi | |
dc.contributor.author | Feng, Xuan | |
dc.contributor.author | Wojnowska, Marta | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2022-11-03T00:40:58Z | |
dc.date.available | 2022-11-03T00:40:58Z | |
dc.date.issued | 2021-11-03 | |
dc.identifier | 276736953 | |
dc.identifier | d05f19e5-01d6-46f7-a6dd-4ba14ac33ba9 | |
dc.identifier | 34779476 | |
dc.identifier | 85120685092 | |
dc.identifier | 000718417700001 | |
dc.identifier.citation | Chen , Y , Zhang , Q , Feng , X , Wojnowska , M & O'Hagan , D 2021 , ' Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4'-fluoroadenosine is identified as a co-product ' , Organic & Biomolecular Chemistry , vol. Advance Article . https://doi.org/10.1039/d1ob01898a | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/103510899 | |
dc.identifier.uri | https://hdl.handle.net/10023/26294 | |
dc.description | Authors thank the Leverhulme Trust, EPSRC and the Sinfonia consortium of the EU for grants as well as the Chinese Scholarship Council for a Studentship (YC), all of which helped to support this work. | en |
dc.description.abstract | Genome homology and the presence of a putative biosynthetic gene cluster identified Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 as candidate producers of the antibiotic nucleocidin 1. Indeed when these bacterial strains were cultured in a medium supplemented with fluoride (4 mM) they each produced nucleocidin 1 and the previously identified 4'-fluoro-3'-O-β-glucosylated adenosine 2 and its sulfamylated derivative 3. In both of these cases 4'-fluoroadenosine 9 is also identified as a natural product although it has never been observed during fermentations of Streptomyces calvus, the original source of nucleocidin 1. The identity of 4'-fluoroadenosine 9 was confirmed by a total synthesis as well as by its in vitro enzymatic conversion to metabolite 2 using the glucosyl transferase enzyme, NucGT. | |
dc.format.extent | 4 | |
dc.format.extent | 872347 | |
dc.format.extent | 2519972 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | AC | en |
dc.subject.lcc | QD | en |
dc.title | Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4'-fluoroadenosine is identified as a co-product | en |
dc.type | Journal article | en |
dc.contributor.sponsor | European Commission | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1039/d1ob01898a | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2022-11-03 | |
dc.identifier.grantnumber | 814418 | en |
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