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Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids
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dc.contributor.author | Ardila, Diana M. | |
dc.contributor.author | Rodriguez, Diego F. | |
dc.contributor.author | Palma, Alirio | |
dc.contributor.author | Diaz, Ivan | |
dc.contributor.author | Cobo, Justo | |
dc.contributor.author | Glidewell, Christopher | |
dc.date.accessioned | 2022-10-26T06:30:15Z | |
dc.date.available | 2022-10-26T06:30:15Z | |
dc.date.issued | 2022-11-01 | |
dc.identifier.citation | Ardila , D M , Rodriguez , D F , Palma , A , Diaz , I , Cobo , J & Glidewell , C 2022 , ' Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids ' , Acta Crystallographica Section C Structural Chemistry , vol. 78 , no. 11 , pp. 671-680 . https://doi.org/10.1107/S2053229622010063 | en |
dc.identifier.issn | 2053-2296 | |
dc.identifier.other | PURE: 281846231 | |
dc.identifier.other | PURE UUID: 1dba7628-ffc0-4c61-b197-ca965b3fcc19 | |
dc.identifier.other | Scopus: 85141889672 | |
dc.identifier.other | WOS: 000886877800010 | |
dc.identifier.uri | https://hdl.handle.net/10023/26246 | |
dc.description | Funding for this research was provided by: Vicerrectoría de Investigación y Extensión of the Industrial University of Santander (grant No. 2680) | en |
dc.description.abstract | Three new 4-styrylquinoline–benzimidazole hybrids have been synthesized using a reaction sequence in which 2-methylquinoline precursors first undergo selective oxidation by selenium dioxide to form the corresponding 2-formylquinoline intermediates, followed by oxidative cyclocondensation reactions with benzene-1,2-diamine to yield the hybrid products. The formyl intermediates and the hybrid products have all been fully characterized using a combination of IR, 1H and 13C NMR spectroscopy, and high-resolution mass spectrometry, and the structures of the three hybrid products have been determined using single-crystal X-ray diffraction. Ethyl (E)-2-(1H-benzo[d]imidazol-2-yl)-4-(4-chlorostyryl)quinoline-3-carboxylate, C27H20ClN3O2, (IIIa), and ethyl (E)-2-(1H-benzo[d]imidazol-2-yl)-4-(2-methoxystyryl)quinoline-3-carboxylate, C28H23N3O3, (IIIb), both crystallize in the solvent-free form with Z′ = 1, but ethyl (E)-2-(1H-benzo[d]imidazol-2-yl)-4-(4-methylstyryl)quinoline-3-carboxylate, C28H23N3O2, (IIIc), crystallizes as a partial hexane solvate with Z′ = 3, and the ester group in one of the independent molecules is disordered over two sets of atomic sites having occupancies of 0.765 (7) and 0.235 (7). The molecules of (IIIc) enclose continuous channels which are occupied by disordered solvent molecules having partial occupancy. In all of the molecules of (IIIa)–(IIIc), the styrylquinoline fragment is markedly nonplanar. Different combinations of N—H⋯O and C—H⋯π hydrogen bonds generate supramolecular assemblies which are two-dimensional in (IIIb) and (IIIc), but three-dimensional in (IIIa). Comparisons are made with the structures of some related compounds. | |
dc.format.extent | 10 | |
dc.language.iso | eng | |
dc.relation.ispartof | Acta Crystallographica Section C Structural Chemistry | en |
dc.rights | Copyright © The Author(s) 2022. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. | en |
dc.subject | Synthesis | en |
dc.subject | Oxidative cyclocondensation | en |
dc.subject | Styrylquinoline | en |
dc.subject | Benzimidazole | en |
dc.subject | Molecular hybrids | en |
dc.subject | Molecular structure | en |
dc.subject | Molecular conformation | en |
dc.subject | Hydrogen bonding | en |
dc.subject | Supramolecular assembly | en |
dc.subject | Crystal structure | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject | NIS | en |
dc.subject | MCC | en |
dc.subject.lcc | QD | en |
dc.title | Synthesis, and spectroscopic and structural characterization of three new styrylquinoline–benzimidazole hybrids | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | https://doi.org/10.1107/S2053229622010063 | |
dc.description.status | Peer reviewed | en |
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