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dc.contributor.authorZeng, Xiangsunze
dc.contributor.authorKomanome, Yuko
dc.contributor.authorKawasaki, Tappei
dc.contributor.authorInada, Kengo
dc.contributor.authorJonaitis, Julius
dc.contributor.authorPulver, Stefan R.
dc.contributor.authorKazama, Hokto
dc.contributor.authorNose, Akinao
dc.date.accessioned2022-10-17T23:39:35Z
dc.date.available2022-10-17T23:39:35Z
dc.date.issued2021-10-18
dc.identifier.citationZeng , X , Komanome , Y , Kawasaki , T , Inada , K , Jonaitis , J , Pulver , S R , Kazama , H & Nose , A 2021 , ' An electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryos ' , Current Biology , vol. In press . https://doi.org/10.1016/j.cub.2021.10.005en
dc.identifier.issn0960-9822
dc.identifier.otherPURE: 276340688
dc.identifier.otherPURE UUID: d494e9a1-a480-4875-874b-7bf45176833e
dc.identifier.otherRIS: urn:34C5ADF55F42DE49D0004CE235F0BC8F
dc.identifier.otherORCID: /0000-0001-5170-7522/work/101958937
dc.identifier.otherScopus: 85120379409
dc.identifier.otherWOS: 000729218600006
dc.identifier.urihttps://hdl.handle.net/10023/26208
dc.descriptionThis work was supported by KAKENHI Grant-in-Aid 19H04742, 18H05113, and 17H05554 to A.N.; 21H04789 and 18H02532 to H.K.; and 19J21596 (JSPS Fellows) to X.Z., and a grant from RIKEN to H.K.en
dc.description.abstractPrecocious movements are widely seen in embryos of various animal species. Whether such movements via proprioceptive feedback play instructive roles in motor development or are a mere reflection of activities in immature motor circuits is a long-standing question. Here we image the emerging motor activities in Drosophila embryos that lack proprioceptive feedback and show that proprioceptive experience is essential for the development of locomotor central pattern generators (CPGs). Downstream of proprioceptive inputs, we identify a pioneer premotor circuit composed of two pairs of segmental interneurons, whose gap-junctional transmission requires proprioceptive experience and plays a crucial role in CPG formation. The circuit autonomously generates rhythmic plateau potentials via IP3-mediated Ca2+ release from internal stores, which contribute to muscle contractions and hence produce proprioceptive feedback. Our findings demonstrate the importance of self-generated movements in instructing motor development and identify the cells, circuit, and physiology at the core of this proprioceptive feedback.
dc.language.isoeng
dc.relation.ispartofCurrent Biologyen
dc.rightsCopyright © 2021 Elsevier Inc. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.cub.2021.10.005en
dc.subjectCentral pattern generatoren
dc.subjectMotor developmenten
dc.subjectProprioceptive feedbacken
dc.subjectGap junctionen
dc.subjectPacemaking activityen
dc.subjectQH301 Biologyen
dc.subjectDASen
dc.subjectACen
dc.subject.lccQH301en
dc.titleAn electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryosen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.identifier.doihttps://doi.org/10.1016/j.cub.2021.10.005
dc.description.statusPeer revieweden
dc.date.embargoedUntil2022-10-18
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0960982221013592?via%3Dihub#app2en


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