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dc.contributor.authorIsrael, Eva M.
dc.contributor.authorComas-Barceló, Júlia
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorWatson, Allan J. B.
dc.identifier.citationIsrael , E M , Comas-Barceló , J , Slawin , A M Z & Watson , A J B 2022 , ' Total synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vector ' , Nature Synthesis , vol. First Online .
dc.identifier.otherPURE: 280991467
dc.identifier.otherPURE UUID: 8e147e0b-40e2-4355-8b9c-6959113df5c7
dc.identifier.otherORCID: /0000-0002-9527-6418/work/121312380
dc.identifier.otherORCID: /0000-0002-1582-4286/work/121312674
dc.identifier.otherScopus: 85170067826
dc.descriptionE.M.I and A.J.B.W. thank Syngenta and EPSRC for an iCASE PhD studentship.en
dc.description.abstractGlobal food security is one of the foremost challenges of our time and requires a multifaceted solution. Crop protection strategies are an essential part of this response; however, there is increasing resistance to known modes of action. Since its discovery in 1949, the natural product alternaric acid has been proposed as a starting point for herbicide development. However, this target is undeveloped due to its poor synthetic accessibility and a lack of knowledge of the associated pharmacology. Here we report the discovery of herbicidal compounds from alternaric acid that operate via a potentially unknown mode of action. Development of a total synthesis enabled structure–activity relationship profiling of compound libraries, which, combined with phenotypic screening and molecular modelling data, identified small-molecule lead compounds with enhanced and broader spectrum herbicidal activity than alternaric acid.
dc.relation.ispartofNature Synthesisen
dc.rightsCopyright © 2022, The Author(s), under exclusive licence to Springer Nature Limited . For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) public copyright Licence to any Accepted Author Manuscript version arising. The final published version of this work is available at
dc.subjectQD Chemistryen
dc.subjectSDG 2 - Zero Hungeren
dc.titleTotal synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vectoren
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.description.statusPeer revieweden

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