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Total synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vector
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dc.contributor.author | Israel, Eva M. | |
dc.contributor.author | Comas-Barceló, Júlia | |
dc.contributor.author | Slawin, Alexandra M. Z. | |
dc.contributor.author | Watson, Allan J. B. | |
dc.date.accessioned | 2022-10-17T10:30:16Z | |
dc.date.available | 2022-10-17T10:30:16Z | |
dc.date.issued | 2022-10-13 | |
dc.identifier.citation | Israel , E M , Comas-Barceló , J , Slawin , A M Z & Watson , A J B 2022 , ' Total synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vector ' , Nature Synthesis , vol. First Online . https://doi.org/10.1038/s44160-022-00169-3 | en |
dc.identifier.issn | 2731-0582 | |
dc.identifier.other | PURE: 280991467 | |
dc.identifier.other | PURE UUID: 8e147e0b-40e2-4355-8b9c-6959113df5c7 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/121312380 | |
dc.identifier.other | ORCID: /0000-0002-1582-4286/work/121312674 | |
dc.identifier.uri | http://hdl.handle.net/10023/26198 | |
dc.description | E.M.I and A.J.B.W. thank Syngenta and EPSRC for an iCASE PhD studentship. | en |
dc.description.abstract | Global food security is one of the foremost challenges of our time and requires a multifaceted solution. Crop protection strategies are an essential part of this response; however, there is increasing resistance to known modes of action. Since its discovery in 1949, the natural product alternaric acid has been proposed as a starting point for herbicide development. However, this target is undeveloped due to its poor synthetic accessibility and a lack of knowledge of the associated pharmacology. Here we report the discovery of herbicidal compounds from alternaric acid that operate via a potentially unknown mode of action. Development of a total synthesis enabled structure–activity relationship profiling of compound libraries, which, combined with phenotypic screening and molecular modelling data, identified small-molecule lead compounds with enhanced and broader spectrum herbicidal activity than alternaric acid. | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Synthesis | en |
dc.rights | Copyright © 2022, The Author(s), under exclusive licence to Springer Nature Limited . For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) public copyright Licence to any Accepted Author Manuscript version arising. The final published version of this work is available at https://doi.org/10.1038/s44160-022-00169-3 | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject | SDG 2 - Zero Hunger | en |
dc.subject.lcc | QD | en |
dc.title | Total synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vector | en |
dc.type | Journal article | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.identifier.doi | https://doi.org/10.1038/s44160-022-00169-3 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2022-10-13 |
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