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dc.contributor.authorIsrael, Eva M.
dc.contributor.authorComas-Barceló, Júlia
dc.contributor.authorSlawin, Alexandra M. Z.
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2022-10-17T10:30:16Z
dc.date.available2022-10-17T10:30:16Z
dc.date.issued2022-10-13
dc.identifier280991467
dc.identifier8e147e0b-40e2-4355-8b9c-6959113df5c7
dc.identifier85170067826
dc.identifier.citationIsrael , E M , Comas-Barceló , J , Slawin , A M Z & Watson , A J B 2022 , ' Total synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vector ' , Nature Synthesis , vol. First Online . https://doi.org/10.1038/s44160-022-00169-3en
dc.identifier.issn2731-0582
dc.identifier.otherORCID: /0000-0002-9527-6418/work/121312380
dc.identifier.otherORCID: /0000-0002-1582-4286/work/121312674
dc.identifier.urihttps://hdl.handle.net/10023/26198
dc.descriptionE.M.I and A.J.B.W. thank Syngenta and EPSRC for an iCASE PhD studentship.en
dc.description.abstractGlobal food security is one of the foremost challenges of our time and requires a multifaceted solution. Crop protection strategies are an essential part of this response; however, there is increasing resistance to known modes of action. Since its discovery in 1949, the natural product alternaric acid has been proposed as a starting point for herbicide development. However, this target is undeveloped due to its poor synthetic accessibility and a lack of knowledge of the associated pharmacology. Here we report the discovery of herbicidal compounds from alternaric acid that operate via a potentially unknown mode of action. Development of a total synthesis enabled structure–activity relationship profiling of compound libraries, which, combined with phenotypic screening and molecular modelling data, identified small-molecule lead compounds with enhanced and broader spectrum herbicidal activity than alternaric acid.
dc.format.extent4966148
dc.language.isoeng
dc.relation.ispartofNature Synthesisen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subjectSDG 2 - Zero Hungeren
dc.subject.lccQDen
dc.titleTotal synthesis and structure-activity-relationship of Alternaric acid delivers an herbicide vectoren
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doi10.1038/s44160-022-00169-3
dc.description.statusPeer revieweden
dc.date.embargoedUntil2022-10-13


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