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A molecular replication process drives supramolecular polymerization
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dc.contributor.author | Feng, Yuanning | |
dc.contributor.author | Philp, Douglas | |
dc.date.accessioned | 2022-10-06T23:39:15Z | |
dc.date.available | 2022-10-06T23:39:15Z | |
dc.date.issued | 2021-10-07 | |
dc.identifier | 276054332 | |
dc.identifier | d4521a23-6124-463c-a772-88d82103375f | |
dc.identifier | 85117462011 | |
dc.identifier | 000710935500017 | |
dc.identifier.citation | Feng , Y & Philp , D 2021 , ' A molecular replication process drives supramolecular polymerization ' , Journal of the American Chemical Society , vol. Articles ASAP . https://doi.org/10.1021/jacs.1c06404 | en |
dc.identifier.issn | 0002-7863 | |
dc.identifier.other | ORCID: /0000-0002-9198-4302/work/100900936 | |
dc.identifier.uri | https://hdl.handle.net/10023/26155 | |
dc.description | This research made use of the IMSERC NMR, MS and PXRD facility at Northwestern University, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-2025633) and Northwestern University. This research made use of the EPIC SEM facility of Northwestern University’s NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-2025633), the IIN, and Northwestern's MRSEC program (NSF DMR-1720139). | en |
dc.description.abstract | Supramolecular polymers are materials in which the connections between monomers in the polymer main chain are non-covalent bonds. This area has seen rapid expansion in the last two decades and has been exploited in several applications. However, suitable contiguous hydrogen bond arrays can be difficult to synthesize, placing some limitations on the deployment of supramolecular polymers. We have designed a hydrogen bonded polymer assembled from a bifunctional monomer composed of two replicating templates separated by a rigid spacer. This design allows the autocatalytic formation of the polymer main chain through the self-templating properties of the replicators and drives the synthesis of the bifunctional monomer from its constituent components in solution. The template-directed 1,3-dipolar cycloaddition reaction between nitrone and maleimide proceeds with high diastereoselectivity affording the bifunctional monomer. The high binding affinity between the self-complementary replicating templates that allow the bifunctional monomer to polymerize in solution is derived from the positive cooperativity associated with this binding process. The assembly of the polymer in solution has been investigated by DOSY NMR spectroscopy. Both microcrystalline and thin films of the polymeric material can be prepared readily and have been characterized by powder X-ray diffraction and scanning electron microscopy. These results demonstrate that the approach described here is a valid one for the construction of supramolecular polymers and can be extended to systems where the rigid spacer between the replicating templates is replaced by one carrying additional function. | |
dc.format.extent | 5226823 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of the American Chemical Society | en |
dc.subject | QD Chemistry | en |
dc.subject | E-NDAS | en |
dc.subject.lcc | QD | en |
dc.title | A molecular replication process drives supramolecular polymerization | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1021/jacs.1c06404 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2022-10-07 |
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