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Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex : a comparison between early-onset smokers and late-onset smokers
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dc.contributor.author | Conti, Aldo | |
dc.contributor.author | Baldacchino, Alexander Mario | |
dc.date.accessioned | 2022-09-07T16:30:07Z | |
dc.date.available | 2022-09-07T16:30:07Z | |
dc.date.issued | 2022-08-26 | |
dc.identifier | 281211290 | |
dc.identifier | 31040579-7286-4c0e-b244-017841459381 | |
dc.identifier | 85138072946 | |
dc.identifier | 000854963700001 | |
dc.identifier.citation | Conti , A & Baldacchino , A M 2022 , ' Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex : a comparison between early-onset smokers and late-onset smokers ' , Frontiers in Psychiatry , vol. 13 , 939707 . https://doi.org/10.3389/fpsyt.2022.939707 | en |
dc.identifier.issn | 1664-0640 | |
dc.identifier.other | ORCID: /0000-0002-5388-7376/work/118799853 | |
dc.identifier.uri | https://hdl.handle.net/10023/25969 | |
dc.description | Funding: This study was supported by the University of St. Andrews Endowment fund. | en |
dc.description.abstract | Introduction: The literature suggests that tobacco smoking may have a neurotoxic effect on the developing adolescent brain. Particularly, it may impair the decision-making process of early-onset smokers (<16 years), by rendering them more prone to impulsive and risky choices toward rewards, and therefore more prone to smoking relapses, in comparison to late-onset smokers (≥16 years). However, no study has ever investigated reward-based decision-making and structural brain differences between early-onset smokers and late-onset smokers. Methods: Computerized measures of reward-based decision-making [Cambridge Gambling Task (CGT); 5-trials adjusting delay discounting task (ADT-5)] were administered to 11 early-onset smokers (mean age at regular smoking initiation = 13.2 years), 17 late-onset smokers (mean age at regular smoking initiation = 18.0 years), and 24 non-smoker controls. Voxel-based morphometry (VBM) was utilized to investigate the gray matter (GM) and white matter (WM) volume differences in fronto-cortical and striatal brain regions between early-onset smokers, late-onset smokers, and non-smokers. Results: Early-onset smokers displayed a riskier decision-making behavior in comparison to non-smokers as assessed by the CGT (p < 0.01, Cohen’s f = 0.48). However, no significant differences (p > 0.05) in reward-based decision-making were detected between early-onset smokers and late-onset smokers. VBM results revealed early-onset smokers to present lower GM volume in the bilateral anterior insular cortex (AI) in comparison to late-onset smokers and lower WM volume in the right AI in comparison to late-onset smokers. Conclusion: Impairments in reward-based decision-making may not be affected by tobacco smoking initiation during early adolescence. Instead, lower GM and WM volume in the AI of early-onset smokers may underline a vulnerability to develop compulsive tobacco seeking and smoking behavior during adulthood. | |
dc.format.extent | 18 | |
dc.format.extent | 2236935 | |
dc.language.iso | eng | |
dc.relation.ispartof | Frontiers in Psychiatry | en |
dc.subject | Insular cortex | en |
dc.subject | Adolescent smokers | en |
dc.subject | Cognitive impulsivity | en |
dc.subject | Voxel based morphometry | en |
dc.subject | Chronic tobacco smoking | en |
dc.subject | Neuroimaging | en |
dc.subject | Addiction | en |
dc.subject | Reward-based decision-making | en |
dc.subject | RA Public aspects of medicine | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | NDAS | en |
dc.subject.lcc | RA | en |
dc.subject.lcc | RC0321 | en |
dc.title | Chronic tobacco smoking, impaired reward-based decision-making, and role of insular cortex : a comparison between early-onset smokers and late-onset smokers | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Centre for Minorities Research (CMR) | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.identifier.doi | https://doi.org/10.3389/fpsyt.2022.939707 | |
dc.description.status | Peer reviewed | en |
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