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dc.contributor.authorGuerendiain, Daniel
dc.contributor.authorGrigorescu, Raluca
dc.contributor.authorKirk, Anna
dc.contributor.authorStevenson, Andrew
dc.contributor.authorHolden, Matthew T. G.
dc.contributor.authorPan, Jiafeng
dc.contributor.authorKavanagh, Kim
dc.contributor.authorGraham, Sheila V.
dc.contributor.authorCuschieri, Kate
dc.date.accessioned2022-07-04T16:30:08Z
dc.date.available2022-07-04T16:30:08Z
dc.date.issued2022-07-04
dc.identifier.citationGuerendiain , D , Grigorescu , R , Kirk , A , Stevenson , A , Holden , M T G , Pan , J , Kavanagh , K , Graham , S V & Cuschieri , K 2022 , ' HPV status and HPV16 viral load in anal cancer and its association with clinical outcome ' , Cancer Medicine , vol. Early View . https://doi.org/10.1002/cam4.4771en
dc.identifier.issn2045-7634
dc.identifier.otherPURE: 280357558
dc.identifier.otherPURE UUID: e6f1e6e0-c88d-435a-82cb-2fd4c6b95c3f
dc.identifier.otherRIS: urn:AB2867527E7623D1B9071E21AD410AED
dc.identifier.otherORCID: /0000-0002-7536-1308/work/115631073
dc.identifier.otherORCID: /0000-0002-4958-2166/work/115631194
dc.identifier.otherScopus: 85133382683
dc.identifier.urihttp://hdl.handle.net/10023/25601
dc.descriptionFunding: KC's institution has received research funding or gratis consumables to support research from the following commercial entities in the last 3years: Cepheid, Euroimmun, GeneFirst, SelfScreen, Hiantis, Seegene, Roche, Abbott and Hologic.en
dc.description.abstractBackground: The incidence of anal cancer is increasing globally. Evidence-based improvement in early detection and management of this morbid cancer is thus required. In other cancers associated with Human Papillomavirus (HPV), viral status and dynamics, including viral load (VL) has been shown to influence clinical outcome. Our aim was to determine the influence of HPV status and HPV16 VL on the clinical outcomes of anal cancer patients. Methods: A total of 185 anal cancer lesions were genotyped for HPV. Of the HPV16 positive component, VL was determined using a digital droplet PCR assay. The association of qualitative HPV status and VL (low (57 copies/cell)) on overall survival and hazard of death was assessed. Results: Of the 185 cases, 164 (88.6%) samples were HPV positive. HPV16 was detected in 154/185 samples (83.2%). HPV positive status was associated with improved overall survival in the univariate analysis [hazard ratio (HR) of 0.44, 0.23–0.82, p = 0.01]. When adjusted by age, sex, stage and response to treatment, the association of positive HPV status with improved survival remained (HR 0.24 [0.11–0.55] p < 0.001). High VL was associated with improved overall survival in the univariate analysis with a HR of 0.28 (0.11–0.71, p = 0.007). When adjusted only by age and sex, high VL was associated with better overall survival (HR 0.27, 0.11–0.68 p = 0.006). Conclusions: HPV status appears to be independently associated with improved outcomes in anal cancer patients. Moreover, HPV viral load quantification may be informative for further risk stratification and warrants further investigation.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofCancer Medicineen
dc.rightsCopyright © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAnal canceren
dc.subjectClinical outcomeen
dc.subjectViral loaden
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectE-DASen
dc.subject.lccRC0254en
dc.titleHPV status and HPV16 viral load in anal cancer and its association with clinical outcomeen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. St Andrews Bioinformatics Uniten
dc.identifier.doihttps://doi.org/10.1002/cam4.4771
dc.description.statusPeer revieweden


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