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dc.contributor.authorHachoumi, Lamia
dc.contributor.authorRensner, Rebecca
dc.contributor.authorRichmond, Claire
dc.contributor.authorPicton, Laurence
dc.contributor.authorZhang, HongYan
dc.contributor.authorSillar, Keith T.
dc.date.accessioned2022-05-30T10:30:16Z
dc.date.available2022-05-30T10:30:16Z
dc.date.issued2022-03-14
dc.identifier.citationHachoumi , L , Rensner , R , Richmond , C , Picton , L , Zhang , H & Sillar , K T 2022 , ' Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord ' , Current Biology , vol. 32 , no. 5 , pp. 1038-1048.e2 . https://doi.org/10.1016/j.cub.2022.01.012en
dc.identifier.issn0960-9822
dc.identifier.otherPURE: 277419127
dc.identifier.otherPURE UUID: f0f73d1f-1094-4bb0-aa79-9231ff10fe04
dc.identifier.otherORCID: /0000-0003-0171-3814/work/107718152
dc.identifier.otherORCID: /0000-0002-9941-4494/work/107718370
dc.identifier.otherScopus: 85125937260
dc.identifier.otherWOS: 000779588200009
dc.identifier.urihttp://hdl.handle.net/10023/25462
dc.descriptionAuthors are grateful for the financial support of this research by the University of St Andrews, the E&RS Neuroscience research fund and BBSRC grant BB/T015705/1.en
dc.description.abstractDynamic neuronal Na+/K+ pumps normally only respond to intense action potential firing owing to their low affinity for intracellular Na+. Recruitment of these Na+ pumps produces a post-activity ultraslow afterhyperpolarization (usAHP) up to ∼10 mV in amplitude and ∼60 s in duration, which influences neuronal properties and future network output. In spinal motor networks, the usAHP underlies short-term motor memory (STMM), reducing the intensity and duration of locomotor network output in a manner dependent on the interval between locomotor bouts. In contrast to tonically active Na+ pumps that help set and maintain the resting membrane potential, dynamic Na+ pumps are selectively antagonized by low concentrations of ouabain, which, we show, blocks both the usAHP and STMM. We examined whether dynamic Na+ pumps and STMM can be influenced by neuromodulators, focusing on 5-HT and nitric oxide. Bath-applied 5-HT alone had no significant effect on the usAHP or STMM. However, this is due to the simultaneous activation of two distinct 5-HT receptor subtypes (5-HT7 and 5-HT2a) that have opposing facilitatory and suppressive influences, respectively, on these two features of the locomotor system. Nitric oxide modulation exerts a potent inhibitory effect that can completely block the usAHP and erase STMM. Using selective blockers of 5-HT7 and 5-HT2a receptors and a nitric oxide scavenger, PTIO, we further provide evidence that the two modulators constitute an endogenous control system that determines how the spinal network self-regulates the intensity of locomotor output in light of recent past experience.
dc.language.isoeng
dc.relation.ispartofCurrent Biologyen
dc.rightsCopyright © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectNa+/K+ pumpen
dc.subjectNeuromodulationen
dc.subjectAfterhyperpolarisationen
dc.subjectShort-term memoryen
dc.subjectMotor controlen
dc.subjectXenopusen
dc.subjectSwimmingen
dc.subjectLocomotionen
dc.subjectSpinal corden
dc.subjectCPGen
dc.subjectQH301 Biologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccQH301en
dc.subject.lccRC0321en
dc.titleBimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal corden
dc.typeJournal articleen
dc.contributor.sponsorBBSRCen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1016/j.cub.2022.01.012
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0960982222000239#app2en
dc.identifier.grantnumberBB/T015705/1en


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