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dc.contributor.advisorSmith, Andrew David
dc.contributor.authorBitai, Jacqueline
dc.coverage.spatialxiii, 256 p.en_US
dc.description.abstractThis thesis details the development of dual catalytic processes involving achiral palladium and enantiopure isothiourea catalysts for the synthesis of enantioenriched and highly functionalised products. Taking inspiration from related literature examples demonstrating the compatibility of palladium and isothiourea catalysis, the extension of existing methodologies as well as the development of novel processes were investigated. Based on the relay catalytic allylic amination/[2,3]-rearrangement protocol, previously developed in our group for the synthesis of enantioenriched α-amino ester derivatives, the scope and limitations of this process were probed. Initial studies aimed at identifying functional groups that could be tolerated in the relay catalysis. Electron-withdrawing amide substituents proved most promising and were explored in more depth to furnish enantioenriched α-amino ester derivatives featuring a 1,4-dicarbonyl motif. As processes reported so far had focused on ammonium enolates as reaction partners, the range of reactivity modes accessible by isothiourea catalysis had not been fully exploited in dual catalytic methodologies. As such, the development of a cooperative palladium and isothiourea catalysis process employing α,β-unsaturated acyl ammonium intermediates was explored. This process furnishes enantioenriched cyclopentane products with up to four contiguous stereogenic centres with high stereoselectivity (up to 99:1 dr, up to 97:3 er). The scope and limitations of this process were probed, with subsequent derivatisation reactions demonstrating the synthetic utility of the products. In addition, a range of control experiments provided insight into the mechanism of this cooperative palladium and isothiourea catalysis.en-US
dc.relationEnantioselective Palladium and Isothiourea Dual Catalysis (Thesis Data) Bitai, J., University of St Andrews, 1 Apr 2024. DOI:
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectFormal (3+2) cycloadditionen_US
dc.subjectAllylic substitutionen_US
dc.subjectEnantioselective dual catalysisen_US
dc.titleEnantioselective palladium and isothiourea dual catalysisen_US
dc.contributor.sponsorUniversity of St Andrews. School of Chemistryen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US
dc.rights.embargoreasonEmbargo period has ended, thesis made available in accordance with University regulationsen

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