Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorVondran, Johanna
dc.contributor.authorFurst, Marc R L
dc.contributor.authorEastham, Graham R
dc.contributor.authorSeidensticker, Thomas
dc.contributor.authorCole-Hamilton, David J
dc.date.accessioned2022-05-06T23:47:07Z
dc.date.available2022-05-06T23:47:07Z
dc.date.issued2021-06-09
dc.identifier274343764
dc.identifier57168d51-6817-43ec-9f91-6e7c90488a26
dc.identifier33961414
dc.identifier85106368336
dc.identifier000662080800007
dc.identifier.citationVondran , J , Furst , M R L , Eastham , G R , Seidensticker , T & Cole-Hamilton , D J 2021 , ' Magic of alpha : the chemistry of a remarkable bidentate phosphine, 1,2-bis(di- tert -butylphosphinomethyl)benzene ' , Chemical Reviews , vol. 121 , no. 11 , pp. 6610-6653 . https://doi.org/10.1021/acs.chemrev.0c01254en
dc.identifier.issn0009-2665
dc.identifier.otherJisc: a16706ca9e34410aa1939286b4925b8d
dc.identifier.urihttps://hdl.handle.net/10023/25317
dc.descriptionWe thank the Fonds der Chemischen Industrie for a Kekulé Fellowship for a studentship and the Deutsche Forschungsgemeinschaft (DFG, project number 424535516) for support (J.V.). We are also very grateful to Lucite International for funding the work in St Andrews that is contained in this review.en
dc.description.abstractThe bidentate phosphine ligand 1,2-bis(di-tert-butylphosphinomethyl)benzene (1,2-DTBPMB) has been reported over the years as being one of, if not the, best ligands for achieving the alkoxycarbonylation of various unsaturated compounds. Bonded to palladium, the ligand provides the basis for the first step in the commercial (Alpha) production of methyl methacrylate as well as very high selectivity to linear esters and acids from terminal or internal double bonds. The present review is an overview covering the literature dealing with the 1,2-DTBPMB ligand: from its first reference, its catalysis, including the alkoxycarbonylation reaction and its mechanism, its isomerization abilities including the highly selective isomerizing methoxycarbonylation, other reactions such as cross-coupling, recycling approaches, and the development of improved, modified ligands, in which some tert-butyl ligands are replaced by 2-pyridyl moieties and which show exceptional rates for carbonylation reactions at low temperatures.
dc.format.extent3783259
dc.language.isoeng
dc.relation.ispartofChemical Reviewsen
dc.subjectHydrocarbonsen
dc.subjectOrganic compoundsen
dc.subjectAlkylsen
dc.subjectLigandsen
dc.subjectSelectivityen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleMagic of alpha : the chemistry of a remarkable bidentate phosphine, 1,2-bis(di-tert-butylphosphinomethyl)benzeneen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doi10.1021/acs.chemrev.0c01254
dc.description.statusPeer revieweden
dc.date.embargoedUntil2022-05-07


This item appears in the following Collection(s)

Show simple item record