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dc.contributor.authorHancox, J
dc.contributor.authorAyling, K
dc.contributor.authorBedford, L
dc.contributor.authorVedhara, K
dc.contributor.authorRoberston, J F R
dc.contributor.authorYoung, B
dc.contributor.authordas Nair, R
dc.contributor.authorSullivan, F M
dc.contributor.authorSchembri, S
dc.contributor.authorMair, F S
dc.contributor.authorLittleford, R
dc.contributor.authorKendrick, D
dc.identifier.citationHancox , J , Ayling , K , Bedford , L , Vedhara , K , Roberston , J F R , Young , B , das Nair , R , Sullivan , F M , Schembri , S , Mair , F S , Littleford , R & Kendrick , D 2022 , ' Psychological impact of lung cancer screening using a novel antibody blood test followed by imaging : the ECLS randomized controlled trial ' , Journal of Public Health .
dc.identifier.otherORCID: /0000-0002-6623-4964/work/110423320
dc.descriptionThis work was supported by the Scottish Government and Oncimmune Ltd. Follow-up data collection for psychological outcome measures was supported by Oncimmune Ltd.en
dc.description.abstractBackground: The Early CDT®-Lung antibody blood test plus serial computed tomography scans for test-positives (TPGs) reduces late-stage lung cancer presentation. This study assessed the psychological outcomes of this approach. Methods: Randomized controlled trial (n = 12 208) comparing psychological outcomes 1-12 months post-recruitment in a subsample (n = 1032) of TPG, test-negative (TNG) and control groups (CG). Results: Compared to TNG, TPG had lower positive affect (difference between means (DBM), 3 months (3m: -1.49 (-2.65, - 0.33)), greater impact of worries (DBM 1m: 0.26 (0.05, 0.47); 3m: 0.28 (0.07, 0.50)), screening distress (DBM 1m: 3.59 (2.28, 4.90); 3m: 2.29 (0.97, 3.61); 6m: 1.94 (0.61, 3.27)), worry about tests (odds ratio (OR) 1m: 5.79 (2.66, 12.63) and more frequent lung cancer worry (OR 1m: 2.52 (1.31, 4.83); 3m: 2.43 (1.26, 4.68); 6m: 2.87 (1.48, 5.60)). Compared to CG, TPG had greater worry about tests (OR 1m: 3.40 (1.69, 6.84)). TNG had lower negative affect (log-transformed DBM 3m: -0.08 (-0.13, -0.02)), higher positive affect (DBM 1m: 1.52 (0.43, 2.61); 3m: 1.43 (0.33, 2.53); 6m: 1.27 (0.17, 2.37)), less impact of worries (DBM 3m: -0.27 (-0.48, -0.07)) and less-frequent lung cancer worry (OR 3m: 0.49 (0.26, 0.92)). Conclusions: Negative psychological effects in TPG and positive effects in TNG were short-lived and most differences were small.
dc.relation.ispartofJournal of Public Healthen
dc.subjectBehavioural medicineen
dc.subjectEarly detection of canceren
dc.subjectLung neoplasmsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titlePsychological impact of lung cancer screening using a novel antibody blood test followed by imaging : the ECLS randomized controlled trialen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

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