Ventx family and its functional similarities with Nanog : involvement in embryonic development and cancer progression
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The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily andbelongs to the NK-like (NKL) subclass. The Ventx family is a homeobox transcription factor and has a DNA-interacting domain evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and human. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia.The therapeutic potential of Ventx family inhibition in combating cancer progression in humans is discussed. Additionally, we briefly discuss genome evolution, gene duplication, pseudo-allotetraploidy, and the homeobox family in Xenopus.
Kumar , S , Kumar , V , Li , W & Kim , J 2022 , ' Ventx family and its functional similarities with Nanog : involvement in embryonic development and cancer progression ' , International Journal of Molecular Sciences , vol. 23 , no. 5 , 2741 . https://doi.org/10.3390/ijms23052741
International Journal of Molecular Sciences
Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons At‐ tribution (CC BY) license (https://creativecommons.org/license/by/4.0/).
DescriptionThis study was supported by Biotechnology and Biological Sciences Research Council-BBSRC-UK (BB/T003146/1) and the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology of Korea (2016R1D1A1B02008770 and 2021M3H9A1097557).
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