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dc.contributor.authorButts, Thomas
dc.contributor.authorHolland, Peter W.H.
dc.contributor.authorFerrier, David Ellard Keith
dc.date.accessioned2012-03-27T23:40:11Z
dc.date.available2012-03-27T23:40:11Z
dc.date.issued2010-11-22
dc.identifier.citationButts , T , Holland , P W H & Ferrier , D E K 2010 , ' Ancient homeobox gene loss and the evolution of chordate brain and pharynx development : deductions from amphioxus gene expression ' , Proceedings of the Royal Society B: Biological Sciences , vol. 277 , no. 1699 , pp. 3381-3389 . https://doi.org/10.1098/rspb.2010.0647en
dc.identifier.issn0962-8452
dc.identifier.otherPURE: 4103492
dc.identifier.otherPURE UUID: 8fcb5719-9ac7-43e0-a52b-9860b79b40db
dc.identifier.otherScopus: 78149256223
dc.identifier.otherORCID: /0000-0003-3247-6233/work/36423833
dc.identifier.urihttp://hdl.handle.net/10023/2473
dc.description.abstractHomeobox genes encode a large superclass of transcription factors with widespread roles in animal development. Within chordates there are over 100 homeobox genes in the invertebrate cephalochordate amphioxus and over 200 in humans. Set against this general trend of increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from vertebrates. Here, we describe the embryonic expression of four amphioxus descendants of these genes—AmphiNedxa, AmphiNedxb, AmphiMsxlx and AmphiNKx7. All four genes are expressed with a striking asymmetry about the left–right axis in the pharyngeal region of neurula embryos, mirroring the pronounced asymmetry of amphioxus embryogenesis. AmphiMsxlx and AmphiNKx7 are also transiently expressed in an anterior neural tube region destined to become the cerebral vesicle. These findings suggest significant rewiring of developmental gene regulatory networks occurred during chordate evolution, coincident with homeobox gene loss. We propose that loss of otherwise widely conserved genes is possible when these genes function in a confined role in development that is subsequently lost or significantly modified during evolution. In the case of these homeobox genes, we propose that this has occurred in relation to the evolution of the chordate pharynx and brain.
dc.language.isoeng
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciencesen
dc.rights© 2010 The Royal Society This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQL Zoologyen
dc.subject.lccQLen
dc.titleAncient homeobox gene loss and the evolution of chordate brain and pharynx development : deductions from amphioxus gene expressionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.identifier.doihttps://doi.org/10.1098/rspb.2010.0647
dc.description.statusPeer revieweden


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