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dc.contributor.authorErbeli, Florina
dc.contributor.authorRice, Marianne
dc.contributor.authorParacchini, Silvia
dc.date.accessioned2022-01-05T13:30:02Z
dc.date.available2022-01-05T13:30:02Z
dc.date.issued2021-12-26
dc.identifier.citationErbeli , F , Rice , M & Paracchini , S 2021 , ' Insights into dyslexia genetics research from the last two decades ' , Brain Sciences , vol. 12 , no. 1 , 27 . https://doi.org/10.3390/brainsci12010027en
dc.identifier.issn2076-3425
dc.identifier.otherPURE: 277243752
dc.identifier.otherPURE UUID: 4dc3917b-9ef5-4cd0-b38a-ca95c255ae02
dc.identifier.otherScopus: 85121972364
dc.identifier.otherWOS: 000757051700001
dc.identifier.urihttp://hdl.handle.net/10023/24599
dc.description.abstractDyslexia, a specific reading disability, is a common (up to 10% of children) and highly heritable (~70%) neurodevelopmental disorder. Behavioral and molecular genetic approaches are aimed towards dissecting its significant genetic component. In the proposed review, we will summarize advances in twin and molecular genetic research from the past 20 years. First, we will briefly outline the clinical and educational presentation and epidemiology of dyslexia. Next, we will summarize results from twin studies, followed by molecular genetic research (e.g., genome-wide association studies (GWASs)). In particular, we will highlight converging key insights from genetic research. (1) Dyslexia is a highly polygenic neurodevelopmental disorder with a complex genetic architecture. (2) Dyslexia categories share a large proportion of genetics with continuously distributed measures of reading skills, with shared genetic risks also seen across development. (3) Dyslexia genetic risks are shared with those implicated in many other neurodevelopmental disorders (e.g., developmental language disorder and dyscalculia). Finally, we will discuss the implications and future directions. As the diversity of genetic studies continues to increase through international collaborate efforts, we will highlight the challenges in advances of genetics discoveries in this field.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofBrain Sciencesen
dc.rightsCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).en
dc.subjectDyslexiaen
dc.subjectGeneticsen
dc.subjectTwin studiesen
dc.subjectMolecular genetic studiesen
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccRC0321en
dc.titleInsights into dyslexia genetics research from the last two decadesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. St Andrews Bioinformatics Uniten
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.3390/brainsci12010027
dc.description.statusPeer revieweden


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