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Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines
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dc.contributor.author | Gilbert, Sophie H. | |
dc.contributor.author | Tin, Sergey | |
dc.contributor.author | Fuentes, José A. | |
dc.contributor.author | Fanjul, Tamara | |
dc.contributor.author | Clarke, Matthew L. | |
dc.date.accessioned | 2021-12-10T00:45:08Z | |
dc.date.available | 2021-12-10T00:45:08Z | |
dc.date.issued | 2020-12-10 | |
dc.identifier | 271680542 | |
dc.identifier | 00adc5db-8195-4b51-a13b-baae19ade6b5 | |
dc.identifier | 85099147880 | |
dc.identifier | 000609617500005 | |
dc.identifier.citation | Gilbert , S H , Tin , S , Fuentes , J A , Fanjul , T & Clarke , M L 2020 , ' Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines ' , Tetrahedron , vol. In Press , 131863 . https://doi.org/10.1016/j.tet.2020.131863 | en |
dc.identifier.issn | 0040-4020 | |
dc.identifier.other | RIS: urn:EF1A0F98DCD41464BCB14588AEA9B8D2 | |
dc.identifier.other | ORCID: /0000-0002-2444-1244/work/85563988 | |
dc.identifier.uri | https://hdl.handle.net/10023/24497 | |
dc.description | We would like to thank the University of St Andrews, and the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) for financial support [Ph.D. studentship to SHG (PhD 2019); Grant code: EP/L016419/1], and Dr Reddys (EU Ltd.) for co-supporting a University studentship to ST (PhD 2017). | en |
dc.description.abstract | An asymmetric hydrogenation of enamines is efficiently catalysed by rhodium complexed with a fluorinated version of the planar chiral paracyclophane-diphosphine ligand, Phanephos. This catalyst was shown to be very active, with examples operating at just 0.1 mol% of catalyst. This catalyst was then successfully adapted to Direct Asymmetric Reductive Amination, leading to the formation of several tertiary amines with moderate e.e., if activated ketone/amine partners are used. | |
dc.format.extent | 762483 | |
dc.language.iso | eng | |
dc.relation.ispartof | Tetrahedron | en |
dc.subject | Enamine hydrogenation | en |
dc.subject | Electronic effects | en |
dc.subject | Enantioselective hydrogenation | en |
dc.subject | Planar chirality | en |
dc.subject | Deuterium labelling | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | Rhodium catalysts derived from a fluorinated phanephos ligand are highly active catalysts for direct asymmetric reductive amination of secondary amines | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1016/j.tet.2020.131863 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2021-12-10 | |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0040402020311212?via=ihub#appsec1 | en |
dc.identifier.grantnumber | EP/L016419/1 | en |
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