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dc.contributor.authorAbbara, Ali
dc.contributor.authorAl-Memar, Maya
dc.contributor.authorPhylactou, Maria
dc.contributor.authorDaniels, Elisabeth
dc.contributor.authorPatel, Bijal
dc.contributor.authorChia Eng, Pei
dc.contributor.authorNadir, Rans
dc.contributor.authorIzzi-Engbeaya, Chioma
dc.contributor.authorClarke, Sophie
dc.contributor.authorMillis, Edouard
dc.contributor.authorHunjan, Tia
dc.contributor.authorPacuszka, Ewa
dc.contributor.authorYang, Lisa
dc.contributor.authorBech, Paul
dc.contributor.authorTan, Tricia
dc.contributor.authorComninos, Alexander
dc.contributor.authorKelsey, Tom
dc.contributor.authorKyriacou, Christopher
dc.contributor.authorFourie, Hanine
dc.contributor.authorBourne, Tom
dc.contributor.authorDhillo, Waljit
dc.date.accessioned2021-12-02T17:30:02Z
dc.date.available2021-12-02T17:30:02Z
dc.date.issued2022-01
dc.identifier.citationAbbara , A , Al-Memar , M , Phylactou , M , Daniels , E , Patel , B , Chia Eng , P , Nadir , R , Izzi-Engbeaya , C , Clarke , S , Millis , E , Hunjan , T , Pacuszka , E , Yang , L , Bech , P , Tan , T , Comninos , A , Kelsey , T , Kyriacou , C , Fourie , H , Bourne , T & Dhillo , W 2022 , ' Changes in circulating kisspeptin levels during each trimester in women with antenatal complications ' , Journal of Clinical Endocrinology & Metabolism , vol. 107 , no. 1 , dgab617 , pp. e71–e83 . https://doi.org/10.1210/clinem/dgab617en
dc.identifier.issn0021-972X
dc.identifier.otherPURE: 275334573
dc.identifier.otherPURE UUID: c0ad7a5a-e90d-4794-9aef-4fa2447134f8
dc.identifier.otherORCID: /0000-0002-8091-1458/work/99115936
dc.identifier.otherWOS: 000753143500012
dc.identifier.otherScopus: 85122625107
dc.identifier.urihttp://hdl.handle.net/10023/24472
dc.descriptionFunding: This paper presents independent research supported by the National Funding: Institute for Health Research (NIHR) Clinical Research Facility and the NIHR Biomedical Research Centre based at Imperial College Healthcare NHS Trust. AA is supported by an NIHR Clinician Scientist award (CS‐2018‐18‐ST2‐002). MAM is funded by the Tommy’s National Centre for Miscarriage Research. MP is supported by an NIHR Academic Clinical Lectureship. CI-E is supported by an Imperial College-BRC IPPRF Fellowship. SAC is supported by an NIHR Academic Clinical Lectureship. EGM is supported by an MRC clinical training fellowship (MR/T006242/1). LY is supported by an MRC clinical training fellowship (MR/R000484/1). ANC is supported by the NHS and BRC. TB is supported by the NIHR Biomedical Research Centre based at Imperial College Healthcare NHS Trust. WSD is supported by an NIHR Research Professorship (RP-2014-05-001).en
dc.description.abstractContext: Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all three trimesters in women with antenatal complications. Objective: To assess whether kisspeptin levels are altered in women with antenatal complications. Methods: Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed. Participants: Women with antenatal complications: HDP (n=32), FGR (n=17), GDM (n=35) and PTB (n=11), and 10 women with multiple complications, provided 373 blood samples, and a further 265 controls provided 930 samples. Results: Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P < 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis. Conclusion: We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolismen
dc.rightsCopyright © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.en
dc.subjectFetal growth restriction (FGR)en
dc.subjectIntrauterine growth restriction (IUGR)en
dc.subjectHypertensive diseases of pregnancy (HDP)en
dc.subjectGestational diabetes (GDM)en
dc.subjectPreterm birth (PTB)en
dc.subjectKisspeptinen
dc.subjectQH301 Biologyen
dc.subjectRG Gynecology and obstetricsen
dc.subject3rd-DASen
dc.subject.lccQH301en
dc.subject.lccRGen
dc.titleChanges in circulating kisspeptin levels during each trimester in women with antenatal complicationsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1210/clinem/dgab617
dc.description.statusPeer revieweden


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