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dc.contributor.authorStarck, Matthieu
dc.contributor.authorFradgley, Jack
dc.contributor.authorDe Rosa, Davide F
dc.contributor.authorBatsanov, Andrei
dc.contributor.authorPapa, Maria
dc.contributor.authorTaylor, Michael
dc.contributor.authorLovett, Janet
dc.contributor.authorLutter, Jacob
dc.contributor.authorAllen, Matthew
dc.contributor.authorParker, David
dc.date.accessioned2021-11-17T13:30:08Z
dc.date.available2021-11-17T13:30:08Z
dc.date.issued2021-11-16
dc.identifier.citationStarck , M , Fradgley , J , De Rosa , D F , Batsanov , A , Papa , M , Taylor , M , Lovett , J , Lutter , J , Allen , M & Parker , D 2021 , ' Versatile para-substituted pyridine lanthanide coordination complexes allow late stage tailoring of complex function ' , Chemistry - A European Journal , vol. Early View . https://doi.org/10.1002/chem.202103243en
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 276564937
dc.identifier.otherPURE UUID: 06e219d0-93cf-442b-8dac-2d10a1551c93
dc.identifier.otherRIS: urn:6FAE723EEF07AF0F790F4D5027FE6478
dc.identifier.otherORCID: /0000-0002-3561-450X/work/103511082
dc.identifier.otherScopus: 85119002063
dc.identifier.urihttp://hdl.handle.net/10023/24350
dc.descriptionWe thank EPSRC, (EP/L01212X/1), for grant support, Cisbio Bioassays for partial studentship support (JDF), and the European Commission for their support (DFR) under an ITN (HEL4CHIROLED 859752). JEL thanks the Royal Society for a University Research Fellowship and doctoral support for MP, BBSRC for BB/T017740/1. MJT thanks EPSRC for doctoral funding (EP/M508214/1). JCL and MJA gratefully acknowledge support from the National Institutes of Health (R01 EB027103).en
dc.description.abstractA series of cationic and neutral p-Br and p-NO2 pyridine substituted Eu(III) and Gd(III) coordination complexes serve as versatile synthetic intermediates. Nucleophilic aromatic substitution occurs readily at the para position under mild conditions, allowing C–N and C–C bond forming reactions to take place, permitting the introduction of azide, amino and alkynyl substituents. For Eu(III) complexes, this approach allows late stage tuning of absorption and emission spectral properties, exemplified by the lowering of the energy of an LMCT transtion accompanied by a reduction in the Eu-Npy bond length. Additionally, these complexes provide direct access to the corresponding Eu(II) analogues. With the Gd(III) series, the nature of the p-substituent does not significantly change the EPR properties (linewidth, relaxation times), as required for their development as EPR spin probes that can be readily conjugated to biomolecules under mild conditions.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.rightsCopyright © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectEuropiumen
dc.subjectGadoliniumen
dc.subjectLuminescenceen
dc.subjectEPRen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleVersatile para-substituted pyridine lanthanide coordination complexes allow late stage tailoring of complex functionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1002/chem.202103243
dc.description.statusPeer revieweden


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