Willin/FRMD6 : a multi-functional neuronal protein associated with Alzheimer’s disease
Abstract
The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype of neuronal cells through ERK signaling. Physiological functions of Willin/FRMD6 in the nervous system include neuronal differentiation, myelination, nerve injury repair, and vesicle exocytosis. The newly established neuronal role of Willin/FRMD6 is of particular interest given the mounting evidence suggesting a role for Willin/FRMD6 in Alzheimer’s disease (AD), including a series of genome wide association studies that position Willin/FRMD6 as a novel AD risk gene. Here we describe recent findings regarding the role of Willin/FRMD6 in the nervous system and its actions in cellular perturbations related to the pathogenesis of AD.
Citation
Chen , D , Yu , W , Aitken , L & Gunn-Moore , F J 2021 , ' Willin/FRMD6 : a multi-functional neuronal protein associated with Alzheimer’s disease ' , Cells , vol. 10 , no. 11 , 3024 . https://doi.org/10.3390/cells10113024
Publication
Cells
Status
Peer reviewed
ISSN
2073-4409Type
Journal item
Description
This research was funded by the EPSRC, grant number EP/P030017 (D.C. and F.G-M), the China Scholarship Council (W.Y.), the Rosetrees Trust and the RS MacDonald Charitable Trust (L.A.).Collections
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