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dc.contributor.authorBauer, Brenda Sarange
dc.contributor.authorAzcoaga-Lorenzo, Amaya
dc.contributor.authorAgrawal, Utkarsh
dc.contributor.authorMcCowan, Colin
dc.date.accessioned2021-11-04T12:30:06Z
dc.date.available2021-11-04T12:30:06Z
dc.date.issued2021-11-01
dc.identifier.citationBauer , B S , Azcoaga-Lorenzo , A , Agrawal , U & McCowan , C 2021 , ' Management strategies for patients with subclinical hypothyroidism : a protocol for an umbrella review ' , Systematic Reviews , vol. 10 , 290 . https://doi.org/10.1186/s13643-021-01842-yen
dc.identifier.issn2046-4053
dc.identifier.otherPURE: 276383190
dc.identifier.otherPURE UUID: 8193e6e5-19f2-4e42-a5bc-826d4e91b469
dc.identifier.otherORCID: /0000-0002-9466-833X/work/102725912
dc.identifier.otherORCID: /0000-0003-3307-878X/work/102725958
dc.identifier.otherORCID: /0000-0002-1417-1260/work/102726021
dc.identifier.otherScopus: 85118548875
dc.identifier.otherWOS: 000713598300002
dc.identifier.urihttps://hdl.handle.net/10023/24259
dc.descriptionFunding: PhD studentship funded by the School of Medicine, University of St Andrews.en
dc.description.abstractBackground: Subclinical hypothyroidism is a thyroid disorder diagnosed from the laboratory blood test results of otherwise asymptomatic patients. It has been associated with poor cardiovascular outcomes, mortality and progression to overt thyroid hormone deficiency. Current guidelines on the management of subclinical hypothyroidism differ because of conflicting evidence on long-term treatment benefits. Even though there are several existing systematic reviews on its clinical outcomes, no definitive conclusion has been reached yet. As such, a new synthesis could help provide more insight and consensus on this topic. To this purpose, this umbrella review will evaluate and synthesise current evidence on the long-term clinical outcomes of the different management strategies for subclinical hypothyroidism. Methods: This is a protocol for an umbrella review on the management strategies for subclinical hypothyroidism. We will conduct literature searches in multiple electronic databases (from inception onwards), namely MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Database of Systematic Reviews, JBI Evidence Synthesis, Epistemonikos database, PDQ Evidence and the PROSPERO register. There will be no restriction on the date or language of publication. Additional material will be identified through grey literature searches and citation chaining. Review inclusion criteria will be patients with subclinical hypothyroidism, receiving treatment or monitoring, no restrictions on the comparators used and with cardiovascular events, frailty fractures, quality of life and all-cause mortality as primary outcomes of interest. Two reviewers will independently screen all citations, full-text articles and abstract data on a pre-piloted form in duplicate. Methodological quality (or bias) of included studies will be appraised using AMSTAR-2. Any conflicts that arise will be resolved through discussion or involving a third reviewer. A narrative synthesis will be provided with information presented in the main text and tables to summarise and explain the characteristics and findings of the included reviews. Even so, it is not expected that a meta-analysis will be performed due to review variability. Study limitations and methodological quality assessments will also be reported to provide context for the overall summary of evidence. Discussion: This review will provide a comprehensive summary of the effects of the pharmacological and non-pharmacological management of subclinical hypothyroidism on specific long-term clinical outcomes. It is anticipated that the findings of this umbrella review will aid in the development of consensus-based clinical recommendations for subclinical hypothyroidism, as well as highlight areas for future research. Review findings will be disseminated primarily through peer-reviewed publications.
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofSystematic Reviewsen
dc.rightsCopyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.subjectSubclinical hypothyroidismen
dc.subjectLevothyroxineen
dc.subjectSystematic reviewen
dc.subjectReview of systematic reviewsen
dc.subjectUmbrella reviewen
dc.subjectRC Internal medicineen
dc.subjectNDASen
dc.subject.lccRCen
dc.titleManagement strategies for patients with subclinical hypothyroidism : a protocol for an umbrella reviewen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doihttps://doi.org/10.1186/s13643-021-01842-y
dc.description.statusPeer revieweden


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