On the effect of age on the transmission of SARS-CoV-2 in households, schools and the community
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Background: There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings. Methods: We reviewed published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, serological studies, and studies of infections in schools. Results: Compared to younger/middle aged adults, susceptibility to infection for children aged under 10y is estimated to be significantly lower, while estimated susceptibility to infection in adults aged over 60y is higher. Serological studies suggest that younger adults (particularly those aged under 35y) often have high cumulative incidence of SARS-CoV-2 infection in the community. There is some evidence that given limited control measures, SARS-CoV-2 may spread robustly in secondary/high schools, and to a lesser degree in primary schools, with class size possibly affecting that spread. There is also evidence of more limited spread in schools when some mitigation measures are implemented. Several potential biases that may affect these studies are discussed. Conclusions: Mitigation measures should be implemented when opening schools, particularly secondary/high schools. Efforts should be undertaken to diminish mixing in younger adults, particularly individuals aged 18-35y to mitigate the spread of the epidemic in the community.
Goldstein , E , Lipsitch , M & Cevik , M 2020 , ' On the effect of age on the transmission of SARS-CoV-2 in households, schools and the community ' , Journal of Infectious Diseases , vol. Advance Article . https://doi.org/10.1093/infdis/jiaa691
Journal of Infectious Diseases
Copyright © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1093/infdis/jiaa691
DescriptionFunding: This work was supported by Award Number U54GM088558 from the National Institute of General Medical Sciences (ML, EG) and the US National Institutes of Health cooperative agreement U01 CA261277 (ML).
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