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A pan-metazoan concept for adult stem cells : the wobbling Penrose landscape
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dc.contributor.author | Rinkevich, Buki | |
dc.contributor.author | Ballarin, Loriano | |
dc.contributor.author | Martinez, Pedro | |
dc.contributor.author | Somorjai, Ildiko Maureen Lara | |
dc.contributor.author | Ben-Hamo, Oshrat | |
dc.contributor.author | Borisenko, Ilya | |
dc.contributor.author | Berezikov, Eugene | |
dc.contributor.author | Ereskovsky, Alexander | |
dc.contributor.author | Gazave, Eve | |
dc.contributor.author | Khnykin, Denis | |
dc.contributor.author | Manni, Lucia | |
dc.contributor.author | Petukhova, Olga | |
dc.contributor.author | Rosner, Amalia | |
dc.contributor.author | Röttinger, Eric | |
dc.contributor.author | Spagnuolo, Antonietta | |
dc.contributor.author | Sugni, Michela | |
dc.contributor.author | Tiozzo, Stefano | |
dc.contributor.author | Hobmayer, Bert | |
dc.date.accessioned | 2021-10-08T11:30:05Z | |
dc.date.available | 2021-10-08T11:30:05Z | |
dc.date.issued | 2021-10-06 | |
dc.identifier | 276069413 | |
dc.identifier | 563b88da-9e51-48b2-af66-9b5dc455e70f | |
dc.identifier | 85116497384 | |
dc.identifier | 000704205100001 | |
dc.identifier.citation | Rinkevich , B , Ballarin , L , Martinez , P , Somorjai , I M L , Ben-Hamo , O , Borisenko , I , Berezikov , E , Ereskovsky , A , Gazave , E , Khnykin , D , Manni , L , Petukhova , O , Rosner , A , Röttinger , E , Spagnuolo , A , Sugni , M , Tiozzo , S & Hobmayer , B 2021 , ' A pan-metazoan concept for adult stem cells : the wobbling Penrose landscape ' , Biological Reviews , vol. Early View . https://doi.org/10.1111/brv.12801 | en |
dc.identifier.issn | 1464-7931 | |
dc.identifier.other | ORCID: /0000-0001-5243-6664/work/101218026 | |
dc.identifier.uri | https://hdl.handle.net/10023/24098 | |
dc.description | Funding: EU COST action MARISTEM. Grant Number: 16203 Marie Skłodowska-Curie COFUND program ARDRE. Grant Number: 847681 National Research Agency, ANR. Grant Numbers: ANR-15-IDEX-01, ANR-19-PRC United States-Israel Binational Science Foundation. Grant Number: 2015012 | en |
dc.description.abstract | Adult stem cells (ASCs) in vertebrates and model invertebrates (e.g. Drosophila melanogaster) are typically long-lived, lineage-restricted, clonogenic and quiescent cells with somatic descendants and tissue/organ-restricted activities. Such ASCs are mostly rare, morphologically undifferentiated, and undergo asymmetric cell division. Characterized by ‘stemness’ gene expression, they can regulate tissue/organ homeostasis, repair and regeneration. By contrast, analysis of other animal phyla shows that ASCs emerge at different life stages, present both differentiated and undifferentiated phenotypes, and may possess amoeboid movement. Usually pluri/totipotent, they may express germ-cell markers, but often lack germ-line sequestering, and typically do not reside in discrete niches. ASCs may constitute up to 40% of animal cells, and participate in a range of biological phenomena, from whole-body regeneration, dormancy, and agametic asexual reproduction, to indeterminate growth. They are considered legitimate units of selection. Conceptualizing this divergence, we present an alternative stemness metaphor to the Waddington landscape: the ‘wobbling Penrose’ landscape. Here, totipotent ASCs adopt ascending/descending courses of an ‘Escherian stairwell’, in a lifelong totipotency pathway. ASCs may also travel along lower stemness echelons to reach fully differentiated states. However, from any starting state, cells can change their stemness status, underscoring their dynamic cellular potencies. Thus, vertebrate ASCs may reflect just one metazoan ASC archetype. | |
dc.format.extent | 27 | |
dc.format.extent | 2606963 | |
dc.language.iso | eng | |
dc.relation.ispartof | Biological Reviews | en |
dc.subject | Regeneration | en |
dc.subject | Asexual reproduction | en |
dc.subject | Adult stem cells | en |
dc.subject | Marine in vertebrates | en |
dc.subject | Niche | en |
dc.subject | Gene expression | en |
dc.subject | Waddington landscape | en |
dc.subject | Germ cells | en |
dc.subject | Totipotency | en |
dc.subject | Cell lineages | en |
dc.subject | QH301 Biology | en |
dc.subject | SDG 14 - Life Below Water | en |
dc.subject.lcc | QH301 | en |
dc.title | A pan-metazoan concept for adult stem cells : the wobbling Penrose landscape | en |
dc.type | Journal item | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Centre for Biophotonics | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. Marine Alliance for Science & Technology Scotland | en |
dc.identifier.doi | 10.1111/brv.12801 | |
dc.description.status | Peer reviewed | en |
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