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Sex differences in zonulin in affective disorders and associations with current mood symptoms
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dc.contributor.author | Maget, A | |
dc.contributor.author | Dalkner, N | |
dc.contributor.author | Hamm, C | |
dc.contributor.author | Bengesser, S A | |
dc.contributor.author | Fellendorf, F T | |
dc.contributor.author | Platzer, M | |
dc.contributor.author | Queissner, R | |
dc.contributor.author | Birner, A | |
dc.contributor.author | Lenger, M | |
dc.contributor.author | Mörkl, S | |
dc.contributor.author | Kohlhammer-Dohr, A | |
dc.contributor.author | Rieger, A | |
dc.contributor.author | Seidl, M | |
dc.contributor.author | Mendel, L | |
dc.contributor.author | Färber, T | |
dc.contributor.author | Wetzlmair, L | |
dc.contributor.author | Schwalsberger, K | |
dc.contributor.author | Amberger-Otti, D V | |
dc.contributor.author | Schöggl, H | |
dc.contributor.author | Lahousen, T | |
dc.contributor.author | Leitner-Afschar, B | |
dc.contributor.author | Unterweger, R | |
dc.contributor.author | Zelzer, S | |
dc.contributor.author | Mangge, H | |
dc.contributor.author | Reininghaus, E Z | |
dc.date.accessioned | 2021-10-04T12:30:16Z | |
dc.date.available | 2021-10-04T12:30:16Z | |
dc.date.issued | 2021-11-01 | |
dc.identifier.citation | Maget , A , Dalkner , N , Hamm , C , Bengesser , S A , Fellendorf , F T , Platzer , M , Queissner , R , Birner , A , Lenger , M , Mörkl , S , Kohlhammer-Dohr , A , Rieger , A , Seidl , M , Mendel , L , Färber , T , Wetzlmair , L , Schwalsberger , K , Amberger-Otti , D V , Schöggl , H , Lahousen , T , Leitner-Afschar , B , Unterweger , R , Zelzer , S , Mangge , H & Reininghaus , E Z 2021 , ' Sex differences in zonulin in affective disorders and associations with current mood symptoms ' , Journal of Affective Disorders , vol. 294 , pp. 441-446 . https://doi.org/10.1016/j.jad.2021.07.021 | en |
dc.identifier.issn | 0165-0327 | |
dc.identifier.other | PURE: 276116653 | |
dc.identifier.other | PURE UUID: 04bd8755-87bc-4493-b67f-0212a159aaf0 | |
dc.identifier.other | PubMed: 34320451 | |
dc.identifier.other | Scopus: 85111032899 | |
dc.identifier.other | ORCID: /0000-0002-5862-9691/work/100901668 | |
dc.identifier.uri | http://hdl.handle.net/10023/24080 | |
dc.description | Zonulin measurement was funded by Institut Allergosan (Graz, Austria). | en |
dc.description.abstract | Introduction: The bidirectional connection between the brain and the gut within psychiatric entities has gained increasing scientific attention over the last years. As a regulator of intestinal permeability, zonulin acts as a key player on the interface of this interplay. Like several psychiatric disorders, intestinal permeability was associated with inflammation in previous findings. Methods: In this study we explored differences in zonulin serum levels in currently depressed (n = 55) versus currently euthymic (n = 37) individuals with an affective disorder. Further, we explored sex differences and possible influences on zonulin and affective symptoms like medication, age, body mass index, and smoking status. Results: Serum zonulin was significantly higher in females than in men independent from affective status (z = -2.412, p = .016). More specifically, females in the euthymic subgroup had higher zonulin levels than euthymic men (z = -2.114, p = .035). There was no difference in zonulin serum levels in individuals taking or not taking a specific psychopharmacotherapy. We found no correlation between zonulin serum levels and depression severity. Discussion: Increased serum zonulin levels as a proxy for increased intestinal permeability in women may indicate a state of elevated susceptibility for depression-inducing stimuli. | |
dc.format.extent | 6 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Affective Disorders | en |
dc.rights | Copyright © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Inflammation | en |
dc.subject | Zonulin | en |
dc.subject | Affective disorders | en |
dc.subject | Intestinal permeability | en |
dc.subject | Depression | en |
dc.subject | Bipolar disorder | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | E-DAS | en |
dc.subject | NIS | en |
dc.subject.lcc | RC0321 | en |
dc.subject.lcc | RM | en |
dc.title | Sex differences in zonulin in affective disorders and associations with current mood symptoms | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.1016/j.jad.2021.07.021 | |
dc.description.status | Peer reviewed | en |
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