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dc.contributor.authorMaget, A
dc.contributor.authorDalkner, N
dc.contributor.authorHamm, C
dc.contributor.authorBengesser, S A
dc.contributor.authorFellendorf, F T
dc.contributor.authorPlatzer, M
dc.contributor.authorQueissner, R
dc.contributor.authorBirner, A
dc.contributor.authorLenger, M
dc.contributor.authorMörkl, S
dc.contributor.authorKohlhammer-Dohr, A
dc.contributor.authorRieger, A
dc.contributor.authorSeidl, M
dc.contributor.authorMendel, L
dc.contributor.authorFärber, T
dc.contributor.authorWetzlmair, L
dc.contributor.authorSchwalsberger, K
dc.contributor.authorAmberger-Otti, D V
dc.contributor.authorSchöggl, H
dc.contributor.authorLahousen, T
dc.contributor.authorLeitner-Afschar, B
dc.contributor.authorUnterweger, R
dc.contributor.authorZelzer, S
dc.contributor.authorMangge, H
dc.contributor.authorReininghaus, E Z
dc.date.accessioned2021-10-04T12:30:16Z
dc.date.available2021-10-04T12:30:16Z
dc.date.issued2021-11-01
dc.identifier.citationMaget , A , Dalkner , N , Hamm , C , Bengesser , S A , Fellendorf , F T , Platzer , M , Queissner , R , Birner , A , Lenger , M , Mörkl , S , Kohlhammer-Dohr , A , Rieger , A , Seidl , M , Mendel , L , Färber , T , Wetzlmair , L , Schwalsberger , K , Amberger-Otti , D V , Schöggl , H , Lahousen , T , Leitner-Afschar , B , Unterweger , R , Zelzer , S , Mangge , H & Reininghaus , E Z 2021 , ' Sex differences in zonulin in affective disorders and associations with current mood symptoms ' , Journal of Affective Disorders , vol. 294 , pp. 441-446 . https://doi.org/10.1016/j.jad.2021.07.021en
dc.identifier.issn0165-0327
dc.identifier.otherPURE: 276116653
dc.identifier.otherPURE UUID: 04bd8755-87bc-4493-b67f-0212a159aaf0
dc.identifier.otherPubMed: 34320451
dc.identifier.otherScopus: 85111032899
dc.identifier.otherORCID: /0000-0002-5862-9691/work/100901668
dc.identifier.urihttp://hdl.handle.net/10023/24080
dc.descriptionZonulin measurement was funded by Institut Allergosan (Graz, Austria).en
dc.description.abstractIntroduction: The bidirectional connection between the brain and the gut within psychiatric entities has gained increasing scientific attention over the last years. As a regulator of intestinal permeability, zonulin acts as a key player on the interface of this interplay. Like several psychiatric disorders, intestinal permeability was associated with inflammation in previous findings. Methods: In this study we explored differences in zonulin serum levels in currently depressed (n = 55) versus currently euthymic (n = 37) individuals with an affective disorder. Further, we explored sex differences and possible influences on zonulin and affective symptoms like medication, age, body mass index, and smoking status. Results: Serum zonulin was significantly higher in females than in men independent from affective status (z = -2.412, p = .016). More specifically, females in the euthymic subgroup had higher zonulin levels than euthymic men (z = -2.114, p = .035). There was no difference in zonulin serum levels in individuals taking or not taking a specific psychopharmacotherapy. We found no correlation between zonulin serum levels and depression severity. Discussion: Increased serum zonulin levels as a proxy for increased intestinal permeability in women may indicate a state of elevated susceptibility for depression-inducing stimuli.
dc.format.extent6
dc.language.isoeng
dc.relation.ispartofJournal of Affective Disordersen
dc.rightsCopyright © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectInflammationen
dc.subjectZonulinen
dc.subjectAffective disordersen
dc.subjectIntestinal permeabilityen
dc.subjectDepressionen
dc.subjectBipolar disorderen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectE-DASen
dc.subject.lccRC0321en
dc.subject.lccRMen
dc.titleSex differences in zonulin in affective disorders and associations with current mood symptomsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1016/j.jad.2021.07.021
dc.description.statusPeer revieweden


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