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Neurokinin 3 receptor antagonists compared with serotonin norepinephrine reuptake inhibitors for non-hormonal treatment of menopausal hot flushes : a systematic qualitative review

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Menown_2021_Adv_Ther_Neurokinin3ReceptorAntagonists_CC.pdf (988.8Kb)
Date
12/09/2021
Author
Menown, Sara J.
Tello, Javier A.
Keywords
Menopause
Vasomotor symptoms
Hot flushes/flashes
Neurokinin 3 receptor antagonist
Fexolinetant
Elinzanetant (NT-814)
MLE4901
Serotonin Norepinephrine Reuptake Inhibitor
Venlafaxine
Desvenlafaxine
RG Gynecology and obstetrics
RM Therapeutics. Pharmacology
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Abstract
Hot flushes/flashes (HFs) or other vasomotor symptoms affect between 45 and 97% of women during menopause. Hormone replacement therapy (HRT) is effective at alleviating menopausal symptoms, but some women cannot or prefer not to take HRT. Since current non-hormonal options have suboptimal efficacy/tolerability, there is a pressing need for an effective, well-tolerated alternative. The neurokinin 3 receptor (NK3R) has recently been implicated in the generation of menopausal HFs and represents a novel therapeutic target to ameliorate HF symptoms. This review aims to assess if NK3R antagonists (NK3Ras) are more effective than Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)—currently a common choice for non-hormonal treatment of menopausal HFs.
Citation
Menown , S J & Tello , J A 2021 , ' Neurokinin 3 receptor antagonists compared with serotonin norepinephrine reuptake inhibitors for non-hormonal treatment of menopausal hot flushes : a systematic qualitative review ' , Advances in Therapy , vol. First Online . https://doi.org/10.1007/s12325-021-01900-w
Publication
Advances in Therapy
Status
Peer reviewed
DOI
https://doi.org/10.1007/s12325-021-01900-w
ISSN
1865-8652
Type
Journal item
Rights
Copyright The Author(s) 2021. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/24016

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