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dc.contributor.authorAbbara, Ali
dc.contributor.authorAl-Memar, Maya
dc.contributor.authorPhylactou, Maria
dc.contributor.authorKyriacou, Christopher
dc.contributor.authorEng, Pei Chia
dc.contributor.authorNadir, Rans
dc.contributor.authorIzzi-Engbeaya, Chioma
dc.contributor.authorClarke, Sophie A.
dc.contributor.authorMills, Edouard G.
dc.contributor.authorDaniels, Elisabeth
dc.contributor.authorHuo, Lechun
dc.contributor.authorPacuszka, Ewa
dc.contributor.authorYang, Lisa
dc.contributor.authorPatel, Bijal
dc.contributor.authorTan, Tricia
dc.contributor.authorBech, Paul
dc.contributor.authorComninos, Alexander N.
dc.contributor.authorFourie, Hanine
dc.contributor.authorKelsey, Tom
dc.contributor.authorBourne, Tom
dc.contributor.authorDhillo, Waljit S.
dc.identifier.citationAbbara , A , Al-Memar , M , Phylactou , M , Kyriacou , C , Eng , P C , Nadir , R , Izzi-Engbeaya , C , Clarke , S A , Mills , E G , Daniels , E , Huo , L , Pacuszka , E , Yang , L , Patel , B , Tan , T , Bech , P , Comninos , A N , Fourie , H , Kelsey , T , Bourne , T & Dhillo , W S 2021 , ' Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimester ' , Fertility and Sterility , vol. 116 , no. 3 , pp. 809-819 .
dc.identifier.otherPURE: 273700366
dc.identifier.otherPURE UUID: d2b3be88-0420-46cd-89fa-308b6d1c5e08
dc.identifier.otherORCID: /0000-0002-8091-1458/work/94669418
dc.identifier.otherScopus: 85107040532
dc.identifier.otherWOS: 000696488100041
dc.descriptionSupported by the National Institute for Health Research (NIHR) Clinical Research Facility and the NIHR Biomedical Research Centre based at Imperial College Healthcare National Health Services (NHS) Trust. The Section of Endocrinology and Investigative Medicine is funded by grants from the Medical Research Council and NIHR. A.A. is supported by an NIHR Clinician Scientist award (CS-2018-18-ST2-002). M.A.M. is supported by Tommy’s National Centre for Miscarriage Research . C.I.-E. is supported by an Imperial College-Biomedical Research Centre Imperial Post-doctoral, Post-CCT Research Fellowship. L.Y. is supported by an Medical Research Council Clinical Training Fellowship (MR/R000484/1). A.N.C. is supported by the NHS and Biomedical Research Centre. T.B. is supported by the NIHR Biomedical Research Centre based at Imperial College Healthcare NHS Trust. W.S.D. is supported by an NIHR Research Professorship (RP-2014-05-001).en
dc.description.abstractObjective: To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester. Design: Prospective, nested case-control study. Setting: Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom. Patient(s): Adult women who had miscarriages (n = 95, 173 samples) and women with healthy pregnancies (n = 265, 557 samples).Intervention(s)The participants underwent serial ultrasound scans and blood sampling for measurement of plasma kisspeptin and βhCG levels during the first trimester. Main Outcome Measure(s): The ability of plasma kisspeptin and βhCG levels to distinguish pregnancies complicated by miscarriage from healthy pregnancies unaffected by miscarriage. Result(s): Gestation-adjusted levels of circulating kisspeptin and βhCG were lower in samples from women with miscarriages than in women with healthy pregnancies by 79% and 70%, respectively. The area under the receiver-operating characteristic curve for identifying miscarriage during the first trimester was 0.874 (95% confidence interval [CI] 0.844–0.904) for kisspeptin, 0.859 (95% CI 0.820–0.899) for βhCG, and 0.916 (95% CI 0.886–0.946) for the sum of the two markers. The performance of kisspeptin in identifying miscarriage improved with increasing length of gestation, whereas that of βhCG worsened. A decision matrix incorporating kisspeptin, βhCG, and gestational age had 83% to 87% accuracy for the prediction of miscarriage. Conclusion(s): Plasma kisspeptin is a promising biomarker for miscarriage and provides additional value to βhCG alone, especially during later gestational weeks of the first trimester.
dc.relation.ispartofFertility and Sterilityen
dc.rightsCopyright © 2021 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine. This is an open access article under the CC BY-NC-ND license (
dc.subjectQH301 Biologyen
dc.subjectRG Gynecology and obstetricsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titlePerformance of plasma kisspeptin as a biomarker for miscarriage improves with gestation during the first trimesteren
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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