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Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets
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dc.contributor.author | Madurasinghe, Vichithranie W. | |
dc.contributor.author | Bower, Peter | |
dc.contributor.author | Eldridge, Sandra | |
dc.contributor.author | Collier, David | |
dc.contributor.author | Graffy, Jonathan | |
dc.contributor.author | Treweek, Shaun | |
dc.contributor.author | Knapp, Peter | |
dc.contributor.author | Parker, Adwoa | |
dc.contributor.author | Rick, Jo | |
dc.contributor.author | Salisbury, Chris | |
dc.contributor.author | Man, Mei See | |
dc.contributor.author | Torgerson, David | |
dc.contributor.author | Sheridan, Rebecca | |
dc.contributor.author | Sullivan, Frank | |
dc.contributor.author | Cockayne, Sarah | |
dc.contributor.author | Dack, Charlotte | |
dc.date.accessioned | 2021-09-23T14:30:10Z | |
dc.date.available | 2021-09-23T14:30:10Z | |
dc.date.issued | 2021-09-23 | |
dc.identifier | 275997223 | |
dc.identifier | 71e8e3a2-cc3b-4cd8-82b1-771747f03b78 | |
dc.identifier | 85115303634 | |
dc.identifier | 34551765 | |
dc.identifier | 000698394800001 | |
dc.identifier.citation | Madurasinghe , V W , Bower , P , Eldridge , S , Collier , D , Graffy , J , Treweek , S , Knapp , P , Parker , A , Rick , J , Salisbury , C , Man , M S , Torgerson , D , Sheridan , R , Sullivan , F , Cockayne , S & Dack , C 2021 , ' Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets ' , BMC Medicine , vol. 19 , 218 . https://doi.org/10.1186/s12916-021-02086-2 | en |
dc.identifier.issn | 1741-7015 | |
dc.identifier.other | RIS: urn:6AD3961A843DE8CA7D6E26938B7F59A1 | |
dc.identifier.other | RIS: Madurasinghe2021 | |
dc.identifier.other | ORCID: /0000-0002-6623-4964/work/100549727 | |
dc.identifier.uri | https://hdl.handle.net/10023/24010 | |
dc.description | Funding: The authors wish to acknowledge the MRC Methodology Research Programme which funds this research (MRC grant reference: G1002325). | en |
dc.description.abstract | Background: The information given to people considering taking part in a trial needs to be easy to understand if those people are to become, and then remain, trial participants. However, there is a tension between providing comprehensive information and providing information that is comprehensible. User-testing is one method of developing better participant information, and there is evidence that user-tested information is better at informing participants about key issues relating to trials. However, it is not clear if user-testing also leads to changes in the rates of recruitment in trials, compared to standard trial information. As part of a programme of research, we embedded ‘studies within a trial’ (SWATs) across multiple ongoing trials to see if user-tested materials led to better rates of recruitment. Methods: Seven ‘host’ trials included a SWAT evaluation and randomised their participants to receive routine information sheets generated by the research teams, or information sheets optimised through user-testing. We collected data on trial recruitment and analysed the results across these trials using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised in a host trial following an invitation to take part. Results: Six SWATs (n=27,805) provided data on recruitment. Optimised participant information sheets likely result in little or no difference in recruitment rates (7.2% versus 6.8%, pooled odds ratio = 1.03, 95% CI 0.90 to 1.19, p-value = 0.63, I2 = 0%). Conclusions: Participant information sheets developed through user testing did not improve recruitment rates. The programme of work showed that co-ordinated testing of recruitment strategies using SWATs is feasible and can provide both definitive and timely evidence on the effectiveness of recruitment strategies. | |
dc.format.extent | 8 | |
dc.format.extent | 659318 | |
dc.language.iso | eng | |
dc.relation.ispartof | BMC Medicine | en |
dc.subject | Recruitment | en |
dc.subject | Information | en |
dc.subject | User-testing | en |
dc.subject | Research methodology | en |
dc.subject | Randomised controlled trial | en |
dc.subject | SWATs | en |
dc.subject | RM Therapeutics. Pharmacology | en |
dc.subject | Medicine(all) | en |
dc.subject | 3rd-NDAS | en |
dc.subject.lcc | RM | en |
dc.title | Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis | en |
dc.contributor.institution | University of St Andrews. Population and Behavioural Science Division | en |
dc.identifier.doi | 10.1186/s12916-021-02086-2 | |
dc.description.status | Peer reviewed | en |
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