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dc.contributor.authorMadurasinghe, Vichithranie W.
dc.contributor.authorBower, Peter
dc.contributor.authorEldridge, Sandra
dc.contributor.authorCollier, David
dc.contributor.authorGraffy, Jonathan
dc.contributor.authorTreweek, Shaun
dc.contributor.authorKnapp, Peter
dc.contributor.authorParker, Adwoa
dc.contributor.authorRick, Jo
dc.contributor.authorSalisbury, Chris
dc.contributor.authorMan, Mei See
dc.contributor.authorTorgerson, David
dc.contributor.authorSheridan, Rebecca
dc.contributor.authorSullivan, Frank
dc.contributor.authorCockayne, Sarah
dc.contributor.authorDack, Charlotte
dc.identifier.citationMadurasinghe , V W , Bower , P , Eldridge , S , Collier , D , Graffy , J , Treweek , S , Knapp , P , Parker , A , Rick , J , Salisbury , C , Man , M S , Torgerson , D , Sheridan , R , Sullivan , F , Cockayne , S & Dack , C 2021 , ' Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets ' , BMC Medicine , vol. 19 , 218 .
dc.identifier.otherRIS: urn:6AD3961A843DE8CA7D6E26938B7F59A1
dc.identifier.otherRIS: Madurasinghe2021
dc.identifier.otherORCID: /0000-0002-6623-4964/work/100549727
dc.descriptionFunding: The authors wish to acknowledge the MRC Methodology Research Programme which funds this research (MRC grant reference: G1002325).en
dc.description.abstractBackground: The information given to people considering taking part in a trial needs to be easy to understand if those people are to become, and then remain, trial participants. However, there is a tension between providing comprehensive information and providing information that is comprehensible. User-testing is one method of developing better participant information, and there is evidence that user-tested information is better at informing participants about key issues relating to trials. However, it is not clear if user-testing also leads to changes in the rates of recruitment in trials, compared to standard trial information. As part of a programme of research, we embedded ‘studies within a trial’ (SWATs) across multiple ongoing trials to see if user-tested materials led to better rates of recruitment. Methods: Seven ‘host’ trials included a SWAT evaluation and randomised their participants to receive routine information sheets generated by the research teams, or information sheets optimised through user-testing. We collected data on trial recruitment and analysed the results across these trials using random effects meta-analysis, with the primary outcome defined as the proportion of participants randomised in a host trial following an invitation to take part. Results: Six SWATs (n=27,805) provided data on recruitment. Optimised participant information sheets likely result in little or no difference in recruitment rates (7.2% versus 6.8%, pooled odds ratio = 1.03, 95% CI 0.90 to 1.19, p-value = 0.63, I2 = 0%). Conclusions: Participant information sheets developed through user testing did not improve recruitment rates. The programme of work showed that co-ordinated testing of recruitment strategies using SWATs is feasible and can provide both definitive and timely evidence on the effectiveness of recruitment strategies.
dc.relation.ispartofBMC Medicineen
dc.subjectResearch methodologyen
dc.subjectRandomised controlled trialen
dc.subjectRM Therapeutics. Pharmacologyen
dc.titleCan we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheetsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

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