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dc.contributor.authorCrowe, Charlotte
dc.contributor.authorMolyneux, Samuel
dc.contributor.authorSharma, Sunil V.
dc.contributor.authorZhang, Ying
dc.contributor.authorGkotsi, Danai S.
dc.contributor.authorConnaris, Helen
dc.contributor.authorGoss, Rebecca J. M.
dc.date.accessioned2021-09-02T07:30:16Z
dc.date.available2021-09-02T07:30:16Z
dc.date.issued2021-09-07
dc.identifier.citationCrowe , C , Molyneux , S , Sharma , S V , Zhang , Y , Gkotsi , D S , Connaris , H & Goss , R J M 2021 , ' Halogenases : a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation ' , Chemical Society Reviews , vol. 17 , no. 50 , pp. 9443-9481 . https://doi.org/10.1039/D0CS01551Ben
dc.identifier.issn0306-0012
dc.identifier.otherPURE: 275629390
dc.identifier.otherPURE UUID: 598b5644-4e6f-4e03-a6fc-435d48bfc6e2
dc.identifier.otherBibtex: D0CS01551B
dc.identifier.otherScopus: 85114347753
dc.identifier.otherWOS: 000696023700008
dc.identifier.urihttp://hdl.handle.net/10023/23888
dc.descriptionAuthors thank ERC GenoChemetics (FP7/2007-2013/ERC consolidator grant GCGXC grant agreement no. 614779 RJMG) for funding, BBSRC Follow on Funding, Synthetic Biology Highlight award. RSE Enterprise Fellowship (SVS), China Scholarship Council and EPSRC CRITICAT EP/L016419/1 for studentship support (Y. Z. & S. M. respectively).en
dc.description.abstractThe enzymatic generation of carbon–halogen bonds is a powerful strategy used by both nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of compounds, opening up the opportunity for selective C–H functionalisation. Genes encoding halogenase enzymes have recently been shown to transcend all kingdoms of life. These enzymes install halogen atoms into aromatic and less activated aliphatic substrates, achieving selectivities that are often challenging to accomplish using synthetic methodologies. Significant advances in both halogenase discovery and engineering have provided a toolbox of enzymes, enabling the ready use of these catalysts in biotransformations, synthetic biology, and in combination with chemical catalysis to enable late stage C–H functionalisation. With a focus on substrate scope, this review outlines the mechanisms employed by the major classes of halogenases, while in parallel, it highlights key advances in the utilisation of the combination of enzymatic halogenation and chemical catalysis for C–H activation and diversification.
dc.format.extent39
dc.language.isoeng
dc.relation.ispartofChemical Society Reviewsen
dc.rightsCopyright © the authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.subjectT-NDASen
dc.subjectACen
dc.subject.lccQDen
dc.titleHalogenases : a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisationen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/D0CS01551B
dc.description.statusPeer revieweden


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