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dc.contributor.authoron behalf of the Scottish Diabetes Research Network (SDRN) Epidemiology Group
dc.contributor.authorJeyam, Anita
dc.contributor.authorGibb, Fraser W.
dc.contributor.authorMcKnight, John A.
dc.contributor.authorKennon, Brian
dc.contributor.authorO’Reilly, Joseph E.
dc.contributor.authorCaparrotta, Thomas M.
dc.contributor.authorHöhn, Andreas
dc.contributor.authorMcGurnaghan, Stuart J.
dc.contributor.authorBlackbourn, Luke A. K.
dc.contributor.authorHatam, Sara
dc.contributor.authorMcCrimmon, Rory J.
dc.contributor.authorLeese, Graham
dc.contributor.authorLindsay, Robert S.
dc.contributor.authorPetrie, John
dc.contributor.authorChalmers, John
dc.contributor.authorPhilip, Sam
dc.contributor.authorWild, Sarah H.
dc.contributor.authorSattar, Naveed
dc.contributor.authorMcKeigue, Paul M.
dc.contributor.authorColhoun, Helen M.
dc.date.accessioned2021-08-26T11:30:12Z
dc.date.available2021-08-26T11:30:12Z
dc.date.issued2021-06
dc.identifier.citationon behalf of the Scottish Diabetes Research Network (SDRN) Epidemiology Group , Jeyam , A , Gibb , F W , McKnight , J A , Kennon , B , O’Reilly , J E , Caparrotta , T M , Höhn , A , McGurnaghan , S J , Blackbourn , L A K , Hatam , S , McCrimmon , R J , Leese , G , Lindsay , R S , Petrie , J , Chalmers , J , Philip , S , Wild , S H , Sattar , N , McKeigue , P M & Colhoun , H M 2021 , ' Marked improvements in glycaemic outcomes following insulin pump therapy initiation in people with type 1 diabetes : a nationwide observational study in Scotland ' , Diabetologia , vol. 64 , no. 6 , pp. 1320-1331 . https://doi.org/10.1007/s00125-021-05413-7en
dc.identifier.issn0012-186X
dc.identifier.otherPURE: 275394460
dc.identifier.otherPURE UUID: c3ef3989-f8b6-40dc-b14a-6c22994bacbe
dc.identifier.othercrossref: 10.1007/s00125-021-05413-7
dc.identifier.otherScopus: 85102314413
dc.identifier.otherORCID: /0000-0002-7170-1205/work/98488312
dc.identifier.urihttp://hdl.handle.net/10023/23842
dc.descriptionThis study was supported by funding from Diabetes UK (17/0005627) and the Chief Scientist Office (ref. ETM/47).en
dc.description.abstractAims/hypothesis Our aim was to assess the use of continuous subcutaneous insulin infusion (CSII) in people with type 1 diabetes in Scotland and its association with glycaemic control, as measured by HbA1c levels, frequency of diabetic ketoacidosis (DKA) and severe hospitalised hypoglycaemia (SHH), overall and stratified by baseline HbA1c. Methods We included 4684 individuals with type 1 diabetes from the national Scottish register, who commenced CSII between 2004 and 2019. We presented crude within-person differences from baseline HbA1c over time since initiation, crude DKA and SHH event-rates pre-/post-CSII exposure. We then used mixed models to assess the significance of CSII exposure, taking into account: (1) the diffuse nature of the intervention (i.e. structured education often precedes initiation); (2) repeated within-person measurements; and (3) background time-trends occurring pre-intervention. Results HbA1c decreased after CSII initiation, with a median within-person change of −5.5 mmol/mol (IQR −12.0, 0.0) (−0.5% [IQR −1.1, 0.0]). Within-person changes were most substantial in those with the highest baseline HbA1c, with median −21.0 mmol/mol (−30.0, −11.0) (−1.9% [−2.7, −1.0]) change in those with a baseline >84 mmol/mol (9.8%) within a year of exposure, that was sustained: −19.0 mmol/mol (−27.6, −6.5) (−1.7% [−2.5, −0.6]) at ≥5 years. Statistical significance and magnitude of change were supported by the mixed models results. The crude DKA event-rate was significantly lower in post-CSII person-time compared with pre-CSII person-time: 49.6 events (95% CI 46.3, 53.1) per 1000 person-years vs 67.9 (64.1, 71.9); rate ratio from Bayesian mixed models adjusting for pre-exposure trend: 0.61 (95% credible interval [CrI] 0.47, 0.77; posterior probability of reduction pp = 1.00). The crude overall SHH event-rate in post-CSII vs pre-CSII person-time was also lower: 17.8 events (95% CI 15.8, 19.9) per 1000 person-years post-exposure vs 25.8 (23.5, 28.3) pre-exposure; rate ratio from Bayesian mixed models adjusting for pre-exposure trend: 0.67 (95% CrI 0.45, 1.01; pp = 0.97). Conclusions/interpretation CSII therapy was associated with marked falls in HbA1c especially in those with high baseline HbA1c. CSII was independently associated with reduced DKA and SHH rates. CSII appears to be an effective option for intensive insulin therapy in people with diabetes for improving suboptimal glycaemic control.
dc.format.extent12
dc.language.isoeng
dc.relation.ispartofDiabetologiaen
dc.rightsCopyright © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectDiabetes mellitus type 1en
dc.subjectHbA1cen
dc.subjectHypoglycaemiaen
dc.subjectInsulin pumpen
dc.subjectKetoacidosisen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectE-DASen
dc.subject.lccRA0421en
dc.titleMarked improvements in glycaemic outcomes following insulin pump therapy initiation in people with type 1 diabetes : a nationwide observational study in Scotlanden
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Geography & Sustainable Developmenten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1007/s00125-021-05413-7
dc.description.statusPeer revieweden


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