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Unlocking the health system barriers to maximise the uptake and utilisation of molecular diagnostics in low- and middle- income country setting

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Date
24/08/2021
Author
Ntinginya, Nyanda Elias
Kuchaka, Davis
Orina, Fred
Mwebaza, Ivan
Liyoyo, Alphonce
Miheso, Barbara
Aturinde, Augustus
Njeleka, Fred
Kiula, Kiula
Msoka, Elizabeth F
Meme, Helen
Sanga, Erica
Mwanyonga, Simeon
Olomi, Willyhelmina
Minja, Linda
Joloba, Moses
Mmbaga, Blandina Theophil
Amukoye, Evans
Gillespie, Stephen Henry
Sabiiti, Wilber
Keywords
Implementaion
Molecular diagnostics
Tuberculosis
Maximising uptake and utilisation
Policy and practice
RA0421 Public health. Hygiene. Preventive Medicine
E-NDAS
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Abstract
Background : Early access to diagnosis is crucial for effective management of any disease including tuberculosis (TB). We investigated the barriers and opportunities to maximise uptake and utilisation of molecular diagnostics in routine healthcare settings. Methods : Using the implementation of World Health Organisation approved TB diagnostics, Xpert MTB/RIF and Line Probe Assay (LPA) as a benchmark we evaluated the barriers and how they could be unlocked to maximise uptake and utilisation of molecular diagnostics. Results : Health officers representing 190 districts/counties participated in the survey across Kenya, Tanzania and Uganda. The survey findings were corroborated by 145 healthcare facility (HCF) audits and 11 policymaker engagement workshops. Xpert MTB/RIF coverage was 66%, falling behind microscopy and clinical diagnosis by 33% and 1% respectively. Stratified by HCF type, Xpert MTB/RIF implementation was 56%, 96% and 95% at district-, regional- and national referral- hospital levels. LPA coverage was 4%, 3% below culture across the three countries. Out of 111 HCFs with Xpert MTB/RIF, 37 (33%) utilised it to full capacity, performing ≥8 tests per day of which 51% of these were level five (zonal consultant and national referral) HCFs. Likewise, 75% of LPA was available at level five HCFs. Underutilisation of Xpert MTB/RIF and LPA was mainly attributed to inadequate- utilities, 26% and human resource, 22%. Underfinancing was the main reason underlying failure to acquire molecular diagnostics. Second to underfinancing was lack of awareness with 33% healthcare administrators and 49% practitioners were unaware of LPA as TB diagnostic. Creation of a health tax and decentralising its management was proposed by policymakers as a booster of domestic financing needed to increase access to diagnostics. Conclusion : Our findings suggest higher uptake and utilisation of molecular diagnostics at tertiary level HCFs contrary to the WHO recommendation. Country-led solutions are crucial for unlocking barriers to increase access to diagnostics.
Citation
Ntinginya , N E , Kuchaka , D , Orina , F , Mwebaza , I , Liyoyo , A , Miheso , B , Aturinde , A , Njeleka , F , Kiula , K , Msoka , E F , Meme , H , Sanga , E , Mwanyonga , S , Olomi , W , Minja , L , Joloba , M , Mmbaga , B T , Amukoye , E , Gillespie , S H & Sabiiti , W 2021 , ' Unlocking the health system barriers to maximise the uptake and utilisation of molecular diagnostics in low- and middle- income country setting ' , BMJ Global Health , vol. 6 , no. 8 , e005357 . https://doi.org/10.1136/bmjgh-2021-005357
Publication
BMJ Global Health
Status
Peer reviewed
DOI
https://doi.org/10.1136/bmjgh-2021-005357
ISSN
2059-7908
Type
Journal article
Rights
Copyright © Author(s) (or their employer(s)) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Description
The study was funded by the European and Developing Countries Clinical Trials Partnership (EDCTP), grant TWENDE-EDCTP-CSA-2014-283.
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  • University of St Andrews Research
URL
https://gh.bmj.com/content/6/8/e005357.full#supplementary-materials
URI
http://hdl.handle.net/10023/23830

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